The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Editor

Share

Personal info

View

Links

  • Homologues
  • NCBI Gene
  • NCBI SNP
  • iHOP resource
  • OMIM
  • SNPedia
  • UniProt
  • Ensembl
  • HGNC

Table of contents

About

Terms

 

Gene Review: 

KCNA4  -  potassium channel, voltage gated shaker...

Homo sapiens

Synonyms: HBK4, HK1, HPCN2, HUKII, KCNA4L, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on KCNA4

  • CaMKII phosphorylation of an amino-terminal residue of KV1.4 leads to slowing of inactivation gating and accelerated recovery from N-type inactivated states [1].
  • The contig spanning 8 Mb from RAG1 to KCNA4 has been assembled by STS and probe content mapping for 76 loci with an average spacing of about 100 kb [2].
  • Its coding region is contained in a single exon, encodes a protein of 654 amino acids, and shares approximately 91% nucleotide sequence identity with human KCNA4/hKv1 [3].
  • Assignment of human potassium channel gene KCNA4 (Kv1.4, PCN2) to chromosome 11q13.4-->q14.1 [4].
  • Increasing 8/G0 muH chain production restores HK1 transcription and improves proliferation of pre-BII cells as well as later stage B cell development [5].
 

Biological context of KCNA4

  • AIMS: To examine and illustrate the morphological characteristics and growth kinetics of Cs-HK1, a Tolypocladium fungus, isolated from wild Cordyceps sinensis in solid and liquid cultures, and the major chemical constituents and antitumour effects of Cs-HK1 mycelium [6].

References

  1. Frequency-dependent inactivation of mammalian A-type K+ channel KV1.4 regulated by Ca2+/calmodulin-dependent protein kinase. Roeper, J., Lorra, C., Pongs, O. J. Neurosci. (1997) [Pubmed]
  2. An integrated YAC clone contig for the WAGR region on human chromosome 11p13-p14.1. Gawin, B., Klamt, B., König, A., Thäte, C., Le Paslier, D., Chumakov, I., Bhogal, R., Zehetner, G., Bruns, G., Gessler, M. Genomics (1995) [Pubmed]
  3. Genomic organization, nucleotide sequence, biophysical properties, and localization of the voltage-gated K+ channel gene KCNA4/Kv1.4 to mouse chromosome 2/human 11p14 and mapping of KCNC1/Kv3.1 to mouse 7/human 11p14.3-p15.2 and KCNA1/Kv1.1 to human 12p13. Wymore, R.S., Korenberg, J.R., Kinoshita, K.D., Aiyar, J., Coyne, C., Chen, X.N., Hustad, C.M., Copeland, N.G., Gutman, G.A., Jenkins, N.A. Genomics (1994) [Pubmed]
  4. Assignment of human potassium channel gene KCNA4 (Kv1.4, PCN2) to chromosome 11q13.4-->q14.1. Philipson, L.H., Eddy, R.L., Shows, T.B., Bell, G.I. Genomics (1993) [Pubmed]
  5. Association of the pre-B cell receptor (BCR) expression level with the quality of pre-BII cell differentiation reveals hierarchical pre-BCR function. Wang, H., Clarke, S.H. Mol. Immunol. (2007) [Pubmed]
  6. Mycelium cultivation, chemical composition and antitumour activity of a Tolypocladium sp. fungus isolated from wild Cordyceps sinensis. Leung, P.H., Zhang, Q.X., Wu, J.Y. J. Appl. Microbiol. (2006) [Pubmed]
Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg
 
WikiGenes - Universities