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Gene Review

BRCA1  -  breast cancer 1, early onset

Canis lupus familiaris

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Disease relevance of BRCA1


High impact information on BRCA1


Biological context of BRCA1


Anatomical context of BRCA1

  • The present study examined immunohistochemically the expression and intracellular distribution of BRCA1 protein in two normal, seven dysplastic and 44 neoplastic canine mammary glands and its relationship with clinical and pathological variables and other prognostic parameters [4].
  • Strong nuclear immunolabelling of BRCA1 protein was observed in the epithelial cells of the normal mammary glands and mammary dysplasias [4].

Analytical, diagnostic and therapeutic context of BRCA1

  • The biological function of BRCA1 and factors affecting expressivity, such as gene-environment and gene-gene interactions, may be more effectively studied in appropriate animal models [1].


  1. Human, canine and murine BRCA1 genes: sequence comparison among species. Szabo, C.I., Wagner, L.A., Francisco, L.V., Roach, J.C., Argonza, R., King, M.C., Ostrander, E.A. Hum. Mol. Genet. (1996) [Pubmed]
  2. Functional assay for BRCA1: mutagenesis of the COOH-terminal region reveals critical residues for transcription activation. Hayes, F., Cayanan, C., Barillà, D., Monteiro, A.N. Cancer Res. (2000) [Pubmed]
  3. Sequence analysis of the rat Brca1 homolog and its promoter region. Bennett, L.M., Brownlee, H.A., Hagavik, S., Wiseman, R.W. Mamm. Genome (1999) [Pubmed]
  4. BRCA1 expression in canine mammary dysplasias and tumours: relationship with prognostic variables. Nieto, A., Pérez-Alenza, M.D., Del Castillo, N., Tabanera, E., Castaño, M., Peña, L. J. Comp. Pathol. (2003) [Pubmed]
  5. Microsatellite polymorphism in intron 14 of the canine BRCA1 gene. Tsuchida, S., Ikemoto, S., Tagawa, M. J. Vet. Med. Sci. (2001) [Pubmed]
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