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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

BRCA1  -  breast cancer 1, early onset

Bos taurus

 
 
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Disease relevance of BRCA1

  • The performance characteristics of the amplified label-free electrochemical detection of DNA hybridization are reported in connection to measurements of nucleic-acid segments related to the breast-cancer BRCA1 gene [1].
  • CONCLUSIONS: In general, OC use, childbearing and breastfeeding do not differ between BRCA1/2 carriers and non-carriers with ovarian cancer [2].
 

High impact information on BRCA1

  • These results provide evidence that phosphorylation and nuclear relocalization are highly conserved features of the BRCA1 response to genotoxic stress [3].
  • Interestingly, when tested in the GAL4 transcriptional activation assay, full-length bovine and human BRCA1 lacked any ability to act as transcriptional activators and the CTD of bovine BRCA1 had five-fold lower activity when compared to the more acidic human C-terminus [3].
  • Human BRCA1 has a genetically demonstrated role in DNA repair, and has been proposed to act as a transcriptional activator in a limited number of specialized settings [3].
  • Expression was characteristically low and diffuse in the nucleus of G1/G0 cells, followed by increasing BRCA1-positive nuclear speckles in late S phase and G2/M phase cells [3].

References

  1. Carbon-nanotube-modified glassy carbon electrodes for amplified label-free electrochemical detection of DNA hybridization. Wang, J., Kawde, A.N., Musameh, M. The Analyst. (2003) [Pubmed]
  2. Reproductive factors and ovarian cancer risk in Jewish BRCA1 and BRCA2 mutation carriers (United States). Modugno, F., Moslehi, R., Ness, R.B., Nelson, D.B., Belle, S., Kant, J.A., Wheeler, J.E., Wonderlick, A., Fishman, D., Karlan, B., Risch, H., Cramer, D.W., Dube, M.P., Narod, S.A. Cancer Causes Control (2003) [Pubmed]
  3. Bovine BRCA1 shows classic responses to genotoxic stress but low in vitro transcriptional activation activity. Krum, S.A., Womack, J.E., Lane, T.F. Oncogene (2003) [Pubmed]
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