Disease relevance of PEAR1

• A one tube-one step RT-PCR was developed for the detection of seven viroids (Apple scar skin viroid, Apple dimple fruit viroid, Pear blister canker viroid, Hop stunt viroid, Chrysanthemum stunt viroid, Citrus exocortis viroid and Peach latent mosaic viroid) in four genera that infect eight plant species [1].

High impact information on PEAR1

• Aggregation-induced PEAR1 tyrosine phosphorylation lead to the subsequent association with the ShcB adaptor protein [2].
• Upon platelet aggregation induced by physiological agonists, PEAR1 became phosphorylated on tyrosine (Tyr-925), and serine (Ser-953 and Ser-1029) residues [2].
• Analysis of the tissue distribution of PEAR1 showed that it was most highly expressed in platelets and endothelial cells [2].
• Sequence analysis of PEAR1 predicts a type-1 membrane protein, 15 extracellular epidermal growth factor-like repeats, and multiple cytoplasmic tyrosines [2].
• When given a choice, psyllids significantly preferred 'Yellow Pear' and avoided PI 134417 for oviposition [3].

Analytical, diagnostic and therapeutic context of PEAR1

• Platelet proximity induced by centrifugation also induced PEAR1 tyrosine phosphorylation, a reaction not inhibited by eptifibatide [2].

References