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Gene Review

CERKL  -  ceramide kinase-like

Homo sapiens

Synonyms: Ceramide kinase-like protein
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Disease relevance of CERKL


High impact information on CERKL

  • We finally identified a novel gene encoding a ceramide kinase (CERKL), which encompassed 13 exons [1].
  • Human CERKL is expressed in the retina, among other adult and fetal tissues [1].
  • Therefore, CERKL deficiency could shift the relative levels of the signaling sphingolipid metabolites and increase sensitivity of photoreceptor and other retinal cells to apoptotic stimuli [1].
  • Our results provide the first evidence of the active nuclear import of CERKL and suggest that the identified NLS might be responsible for nucleolar retention of the protein [2].
  • Identification of a nuclear localization signal in the retinitis pigmentosa-mutated RP26 protein, ceramide kinase-like protein [2].

Biological context of CERKL


Anatomical context of CERKL

  • Upon 32P(i)-pulse labeling of COS-1 cells transiently expressing CERKL, or incubation with NBD-C6-ceramide, ceramide-1-phosphate was not detected [3].

Associations of CERKL with chemical compounds


Other interactions of CERKL


  1. Mutation of CERKL, a novel human ceramide kinase gene, causes autosomal recessive retinitis pigmentosa (RP26). Tuson, M., Marfany, G., Gonzàlez-Duarte, R. Am. J. Hum. Genet. (2004) [Pubmed]
  2. Identification of a nuclear localization signal in the retinitis pigmentosa-mutated RP26 protein, ceramide kinase-like protein. Inagaki, Y., Mitsutake, S., Igarashi, Y. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  3. Characterization of a ceramide kinase-like protein. Bornancin, F., Mechtcheriakova, D., Stora, S., Graf, C., Wlachos, A., Dévay, P., Urtz, N., Baumruker, T., Billich, A. Biochim. Biophys. Acta (2005) [Pubmed]
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