Disease relevance of KCNG1

• K19 was expressed mainly in moderately and poorly differentiated tumors, and K13 was manifest more in well-differentiated carcinomas or in keratinized areas of less-differentiated ones [1].

High impact information on KCNG1

• The temperature dependency for each rate constant was defined with experimentally determined values for A and E and the Arrhenius expression, kT = Ae-E/RT, where kT represented kH1, kH2 , kS, kOH, kGA, or kGB [2].
• Fluorescence in situ hybridization localized kH1 to the human chromosome 2p25 and kH2 to the human chromosome 20q13 [3].
• Unlike kH1, 2.4 kb of kH2 was expressed predominantly in the brain, placenta, and the skeletal muscle where it shared a differently spliced form of the kH2 mRNA, approximately 2.0 kb [3].
• Petraki et al have previously described presence of hK13 in salivary gland tissue, localized to duct epithelia and some acinar cells [4].
• At 10(-7) M retinoic acid, the cells form a ciliated pseudostratified epithelium, with no expression of K13 [5].

Biological context of KCNG1

• Two novel human genes encoding putative potassium channels, kH1 and kH2, were identified from a human fetal brain cDNA library [3].

References