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Gene Review

KCNF1  -  potassium channel, voltage gated modifier...

Homo sapiens

Synonyms: IK8, KCNF, KV5.1, Kv5.1, Potassium voltage-gated channel subfamily F member 1, ...
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High impact information on KCNF1

  • Three candidate genes, KCNF1, ID2 and ATP6V1C2 were sequenced, and were found to be negative for functional sequence variants [1].
  • The temperature dependency for each rate constant was defined with experimentally determined values for A and E and the Arrhenius expression, kT = Ae-E/RT, where kT represented kH1, kH2 , kS, kOH, kGA, or kGB [2].
  • Northern blot studies revealed that one mRNA species, approximately 5kb, of the kH1 was expressed abundantly in tissues examined, including the heart, skeletal muscle, and less abundant in the brain, liver, kidney, and pancreas [3].
  • Two novel human genes encoding putative potassium channels, kH1 and kH2, were identified from a human fetal brain cDNA library [3].
  • Fluorescence in situ hybridization localized kH1 to the human chromosome 2p25 and kH2 to the human chromosome 20q13 [3].


  1. A novel autosomal recessive non-syndromic hearing impairment locus (DFNB47) maps to chromosome 2p25.1-p24.3. Hassan, M.J., Santos, R.L., Rafiq, M.A., Chahrour, M.H., Pham, T.L., Wajid, M., Hijab, N., Wambangco, M., Lee, K., Ansar, M., Yan, K., Ahmad, W., Leal, S.M. Hum. Genet. (2006) [Pubmed]
  2. Influence of pH, temperature and buffers on cefepime degradation kinetics and stability predictions in aqueous solutions. Fubara, J.O., Notari, R.E. Journal of pharmaceutical sciences. (1998) [Pubmed]
  3. Isolation, characterization, and mapping of two human potassium channels. Su, K., Kyaw, H., Fan, P., Zeng, Z., Shell, B.K., Carter, K.C., Li, Y. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
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