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Gene Review:

Synpcc7942_1217 - circadian clock protein KaiB

Synechococcus elongatus PCC 7942

This record was discontinued.

Xu, Y. et al., Nakahira, Y. et al., Iwasaki, H. et al., Ishiura, M. et al.

Ishiura, Kutsuna, Aoki, Iwasaki, Andersson, Tanabe, Golden, Johnson, Kondo,

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Disease relevance of Synpcc7942_1217

The kai gene cluster, which is composed of three genes, kaiA, kaiB and kaiC, is essential for the generation of circadian rhythms in the unicellular cyanobacterium Synechococcus sp. strain PCC 7942 [1].
Using model strains in which we ectopically express the cyanobacterial clock protein KaiC in cells from which the clock genes kaiA, kaiB and/or kaiC are deleted, we found that some features of circadian clocks in eukaryotic organisms are conserved in the clocks of prokaryotic cyanobacteria, but others are not [2].
We also found that a promoter derived from E. coli is feedback controlled by KaiC and restores the complete circadian rhythm in kaiBC-inactivated arrhythmic mutants, provided it can express kaiB and kaiC genes at an appropriate level [3].

High impact information on Synpcc7942_1217

Promoter activities upstream of the kaiA and kaiB genes showed circadian rhythms of expression, and both kaiA and kaiBC messenger RNAs displayed circadian cycling [4].

References

Physical interactions among circadian clock proteins KaiA, KaiB and KaiC in cyanobacteria. Iwasaki, H., Taniguchi, Y., Ishiura, M., Kondo, T. EMBO J. (1999) [Pubmed]
Cyanobacterial circadian clockwork: roles of KaiA, KaiB and the kaiBC promoter in regulating KaiC. Xu, Y., Mori, T., Johnson, C.H. EMBO J. (2003) [Pubmed]
Global gene repression by KaiC as a master process of prokaryotic circadian system. Nakahira, Y., Katayama, M., Miyashita, H., Kutsuna, S., Iwasaki, H., Oyama, T., Kondo, T. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
Expression of a gene cluster kaiABC as a circadian feedback process in cyanobacteria. Ishiura, M., Kutsuna, S., Aoki, S., Iwasaki, H., Andersson, C.R., Tanabe, A., Golden, S.S., Johnson, C.H., Kondo, T. Science (1998) [Pubmed]

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