Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

CYBB - cytochrome b-245, beta polypeptide

Bos taurus

Zhang, A.Y. et al., Hwang, J. et al., Sankarapandi, S. et al.

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High impact information on CYBB

Western blots of microglia lysates demonstrated that both large (gp91-phox) and small (p22-phox) NADPH oxidase subunits are expressed in both unstimulated and stimulated microglia [1].
Interestingly, double labeling of a membrane-bound NADPH oxidase subunit, gp91phox, and LRs showed that gp91phox colocalized within the LR patches when endothelial cells were stimulated by Fas ligand [2].
In isolated LR fractions from Fas-stimulated endothelial cells, gp91phox, p47phox (a crucial cytosolic regulatory subunit of NADPH oxidase), and Rac GTPase were markedly increased and blocked by nystatin, a compound that disrupts LRs [2].
In contrast, pulsatile flow downregulated both gp91phox and Nox4 mRNA expression (by 1.8+/-0.2-fold and 3.0+/-0.12-fold, respectively), with an accompanying reduction in O2-* production, reduction in the extent of LDL modification (51+/-12% for LDL- and 30+/-7% for LDL2-), and monocyte/BAEC binding [3].

References

Measurement and characterization of superoxide generation in microglial cells: evidence for an NADPH oxidase-dependent pathway. Sankarapandi, S., Zweier, J.L., Mukherjee, G., Quinn, M.T., Huso, D.L. Arch. Biochem. Biophys. (1998) [Pubmed]
Lipid raft clustering and redox signaling platform formation in coronary arterial endothelial cells. Zhang, A.Y., Yi, F., Zhang, G., Gulbins, E., Li, P.L. Hypertension (2006) [Pubmed]
Pulsatile versus oscillatory shear stress regulates NADPH oxidase subunit expression: implication for native LDL oxidation. Hwang, J., Ing, M.H., Salazar, A., Lassègue, B., Griendling, K., Navab, M., Sevanian, A., Hsiai, T.K. Circ. Res. (2003) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

AT1G19230	Arabidopsis thaliana
CYBB	Canis lupus familiaris
cybb	Danio rerio
CYBB	Gallus gallus
CYBB	Homo sapiens
CYBB	Macaca mulatta
MGG_06559	Magnaporthe oryzae 70-15
Cybb	Mus musculus
NCU10775	Neurospora crassa OR74A
Os08g0453700	Oryza sativa Japonica Group
Os09g0438000	Oryza sativa Japonica Group
LOC465566	Pan troglodytes
Cybb	Rattus norvegicus
cybb	Xenopus (Silurana) tropicalis

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