Gene Review:
HMGA2 - high mobility group AT-hook 2
Homo sapiens
Synonyms:
BABL, HMGI-C, HMGIC, High mobility group AT-hook protein 2, High mobility group protein HMGI-C, ...
John Schiltz,
Queimado,
Vacca,
Diana,
Zani,
Lopes,
Kathleen Benson,
Giannini,
Peverali,
Crescenzi,
Ristori,
Tallini,
De Wever,
Sciot,
Scarpa,
Johnson,
Li,
Annie Pardo,
Moises Selman,
Gulino,
Tallini,
Kazushi Imai,
David Sternberg,
Piaggio,
Murty Vundavalli,
Li,
Jeanine D'Armiento,
Joshua Sonnet,
Matthias Szabolcs,
Reis,
Theresa Smolarek,
Hui,
Natalya Kolesnekova,
Manfioletti,
Di Marcotullio,
Screpanti,
Frati,
Kiran Chada,
Manfioletti,
Hui,
McNiff,
- Aberrant expression of HMGA2 in uterine leiomyoma associated with loss of TSC2 tumor suppressor gene function. Hunter, D.S., Klotzbücher, M., Kugoh, H., Cai, S.L., Mullen, J.P., Manfioletti, G., Fuhrman, U., Walker, C.L. Cancer Res. (2002)
- Increased expression of high mobility group A proteins in lung cancer. Sarhadi, V.K., Wikman, H., Salmenkivi, K., Kuosma, E., Sioris, T., Salo, J., Karjalainen, A., Knuutila, S., Anttila, S. J. Pathol. (2006)
- Repression of HMGA2 Gene Expression by Human Cytomegalovirus Involves the IE2 86-Kilodalton Protein and Is Necessary for Efficient Viral Replication and Inhibition of Cyclin A Transcription. Shlapobersky, M., Sanders, R., Clark, C., Spector, D.H. J. Virol. (2006)
- The tumor suppressor microRNA let-7 represses the HMGA2 oncogene. Lee, Y.S., Dutta, A. Genes Dev. (2007)
- Identification of the benign mesenchymal tumor gene HMGA2 in lymphangiomyomatosis. D'Armiento, J., Imai, K., Schiltz, J., Kolesnekova, N., Sternberg, D., Benson, K., Pardo, A., Selman, M., Smolarek, T., Vundavalli, M., Sonnet, J., Szabolcs, M., Chada, K. Cancer Res. (2007)
- Overexpression of HMGA2 Promotes Metastasis and Impacts Survival of Colorectal Cancers. Wang, X., Liu, X., Li, A.Y., Chen, L., Lai, L., Lin, H.H., Hu, S., Yao, L., Peng, J., Loera, S., Xue, L., Zhou, B., Zhou, L., Zheng, S., Chu, P., Zhang, S., Ann, D.K., Yen, Y. Clin. Cancer Res. (2011)
- Concentrations of adipsin in blood and rates of adipsin secretion by adipose tissue in humans with normal, elevated and diminished adipose tissue mass. Napolitano, A., Lowell, B.B., Damm, D., Leibel, R.L., Ravussin, E., Jimerson, D.C., Lesem, M.D., Van Dyke, D.C., Daly, P.A., Chatis, P. Int. J. Obes. Relat. Metab. Disord. (1994)
- A novel role for high-mobility group a proteins in cellular senescence and heterochromatin formation. Narita, M., Narita, M., Krizhanovsky, V., Nuñez, S., Chicas, A., Hearn, S.A., Myers, M.P., Lowe, S.W. Cell (2006)
- Recurrent rearrangements in the high mobility group protein gene, HMGI-C, in benign mesenchymal tumours. Schoenmakers, E.F., Wanschura, S., Mols, R., Bullerdiek, J., Van den Berghe, H., Van de Ven, W.J. Nat. Genet. (1995)
- Disruption of the architectural factor HMGI-C: DNA-binding AT hook motifs fused in lipomas to distinct transcriptional regulatory domains. Ashar, H.R., Fejzo, M.S., Tkachenko, A., Zhou, X., Fletcher, J.A., Weremowicz, S., Morton, C.C., Chada, K. Cell (1995)
- HMGA proteins in malignant peripheral nerve sheath tumor and synovial sarcoma: preferential expression of HMGA2 in malignant peripheral nerve sheath tumor. Hui, P., Li, N., Johnson, C., De Wever, I., Sciot, R., Manfioletti, G., Tallini, G. Mod. Pathol. (2005)
- High mobility group A2 potentiates genotoxic stress in part through the modulation of basal and DNA damage-dependent phosphatidylinositol 3-kinase-related protein kinase activation. Boo, L.M., Lin, H.H., Chung, V., Zhou, B., Louie, S.G., O'Reilly, M.A., Yen, Y., Ann, D.K. Cancer Res. (2005)
- Expression profile of the tumorigenic factors associated with tumor size and sex steroid hormone status in uterine leiomyomata. Wei, J.J., Chiriboga, L., Mittal, K. Fertil. Steril. (2005)
- Genomic changes in endometrial polyps associated with tamoxifen show no evidence for its action as an external carcinogen. Dal Cin, P., Timmerman, D., Van den Berghe, I., Wanschura, S., Kazmierczak, B., Vergote, I., Deprest, J., Neven, P., Moerman, P., Bullerdiek, J., Van den Berghe, H. Cancer Res. (1998)
- HMGI(Y) and HMGI-C genes are expressed in neuroblastoma cell lines and tumors and affect retinoic acid responsiveness. Giannini, G., Di Marcotullio, L., Ristori, E., Zani, M., Crescenzi, M., Scarpa, S., Piaggio, G., Vacca, A., Peverali, F.A., Diana, F., Screpanti, I., Frati, L., Gulino, A. Cancer Res. (1999)
- Transcriptional activation of the cyclin A gene by the architectural transcription factor HMGA2. Tessari, M.A., Gostissa, M., Altamura, S., Sgarra, R., Rustighi, A., Salvagno, C., Caretti, G., Imbriano, C., Mantovani, R., Del Sal, G., Giancotti, V., Manfioletti, G. Mol. Cell. Biol. (2003)
- Fusion transcripts involving HMGA2 are not a common molecular mechanism in uterine leiomyomata with rearrangements in 12q15. Quade, B.J., Weremowicz, S., Neskey, D.M., Vanni, R., Ladd, C., Dal Cin, P., Morton, C.C. Cancer Res. (2003)
- Human HMGA2 promoter is coregulated by a polymorphic dinucleotide (TC)-repeat. Borrmann, L., Seebeck, B., Rogalla, P., Bullerdiek, J. Oncogene (2003)
- HMGA molecules in neuroblastic tumors. Cerignoli, F., Ambrosi, C., Mellone, M., Assimi, I., di Marcotullio, L., Gulino, A., Giannini, G. Ann. N. Y. Acad. Sci. (2004)
- Transactivation functions of the tumor-specific HMGA2/LPP fusion protein are augmented by wild-type HMGA2. Crombez, K.R., Vanoirbeek, E.M., Van de Ven, W.J., Petit, M.M. Mol. Cancer Res. (2005)
- Expression of mesenchyme-specific gene HMGA2 in squamous cell carcinomas of the oral cavity. Miyazawa, J., Mitoro, A., Kawashiri, S., Chada, K.K., Imai, K. Cancer Res. (2004)
- Fenofibrate increases the expression of high mobility group AT-hook 2 (HMGA2) gene and induces adipocyte differentiation of orbital fibroblasts from Graves' ophthalmopathy. Pasquali, D., Pierantoni, G.M., Fusco, A., Staibano, S., Colantuoni, V., De Bellis, A., Bellastella, A., Sinisi, A.A. J. Mol. Endocrinol. (2004)
- High mobility group A2 protein and its derivatives bind a specific region of the promoter of DNA repair gene ERCC1 and modulate its activity. Borrmann, L., Schwanbeck, R., Heyduk, T., Seebeck, B., Rogalla, P., Bullerdiek, J., Wisniewski, J.R. Nucleic Acids Res. (2003)
- Evidence for RAD51L1/HMGIC fusion in the pathogenesis of uterine leiomyoma. Takahashi, T., Nagai, N., Oda, H., Ohama, K., Kamada, N., Miyagawa, K. Genes Chromosomes Cancer (2001)
- The expression of HMGA genes is regulated by their 3'UTR. Borrmann, L., Wilkening, S., Bullerdiek, J. Oncogene (2001)
- WIF1, an inhibitor of the Wnt pathway, is rearranged in salivary gland tumors. Queimado, L., Lopes, C.S., Reis, A.M. Genes Chromosomes Cancer (2007)
- Overexpression of HMGA2-LPP fusion transcripts promotes expression of the alpha 2 type XI collagen gene. Kubo, T., Matsui, Y., Goto, T., Yukata, K., Yasui, N. Biochem. Biophys. Res. Commun. (2006)
- Differential expression of HMGA1 and HMGA2 in dermatofibroma and dermatofibrosarcoma protuberans: potential diagnostic applications, and comparison with histologic findings, CD34, and factor XIIIa immunoreactivity. Li, N., McNiff, J., Hui, P., Manfioletti, G., Tallini, G. The American Journal of dermatopathology. (2004)
- Molecular dissection of the architectural transcription factor HMGA2. Noro, B., Licheri, B., Sgarra, R., Rustighi, A., Tessari, M.A., Chau, K.Y., Ono, S.J., Giancotti, V., Manfioletti, G. Biochemistry (2003)
- The High Mobility Group A2 gene is amplified and overexpressed in human prolactinomas. Finelli, P., Pierantoni, G.M., Giardino, D., Losa, M., Rodeschini, O., Fedele, M., Valtorta, E., Mortini, P., Croce, C.M., Larizza, L., Fusco, A. Cancer Res. (2002)