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Gene Review

CREM  -  cAMP responsive element modulator

Gallus gallus

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High impact information on ICER

  • The CREM product, ICER, is rhythmically expressed and participates in a transcriptional autoregulatory loop which also controls the amplitude of oscillations of serotonin N-acetyl transferase (AANAT), the rate-limiting enzyme of melatonin synthesis [1].


  1. Rhythmic transcription: the molecular basis of circadian melatonin synthesis. Foulkes, N.S., Whitmore, D., Sassone-Corsi, P. Biol. Cell (1997) [Pubmed]
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