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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

CREM  -  cAMP responsive element modulator

Canis lupus familiaris

 
 
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High impact information on CREM

  • In response to TSH, CREB/CREM transcription factors were phosphorylated on the serine residue of the pyruvate kinase A consensus site [1].
  • Together these results show that CREB/CREM transcription factors are tightly regulated, at the transcriptional and post-translational levels, by TSH in dog thyroid cells, and provide clear evidence that their activity is required for the cAMP-dependent proliferation of cells in primary culture [1].
  • Regulation of gene expression by cAMP involves phosphorylation by pyruvate kinase A and activation of cAMP-response element binding protein (CREB)/CRE modulator (CREM) transcription factors which bind DNA to CRE sites [1].
  • The ectopic expression of ICER Igamma or CREM alpha isoforms inhibited DNA replication in dog thyrocytes stimulated by TSH [1].
  • Dog CREM transcription factors: cloning, tissue distribution, and identification of new isoforms [2].

References

  1. Requirement for cAMP-response element (CRE) binding protein/CRE modulator transcription factors in thyrotropin-induced proliferation of dog thyroid cells in primary culture. Uyttersprot, N., Costagliola, S., Dumont, J.E., Miot, F. Eur. J. Biochem. (1999) [Pubmed]
  2. Dog CREM transcription factors: cloning, tissue distribution, and identification of new isoforms. Uyttersprot, N., Miot, F. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
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