Gene Review:
CREM - cAMP responsive element modulator
Homo sapiens
Synonyms:
CREM-2, ICER, Inducible cAMP early repressor, cAMP-responsive element modulator, hCREM-2
Steger,
Klonisch,
Gavenis,
Behr,
Schaller,
Drabent,
Doenecke,
Nieschlag,
Bergmann,
Weinbauer,
Müller,
Bokník,
Knapp,
Neumann,
Vahlensieck,
Oetjen,
Scheld,
Schmitz,
Don,
Stelzer,
Inada,
Someya,
Yamada,
Ihara,
Kubota,
Ban,
Watanabe,
Tsuda,
Seino,
Ho,
Terriff,
Price,
Wloka,
Chik,
Krzyzanowska,
Earle,
Kuntz,
Weeks,
Bodor,
Habener,
- The cyclic adenosine 5'-monophosphate response element modulator suppresses IL-2 production in stimulated T cells by a chromatin-dependent mechanism. Tenbrock, K., Juang, Y.T., Tolnay, M., Tsokos, G.C. J. Immunol. (2003)
- Variable expression of the transcription factors cAMP response element-binding protein and inducible cAMP early repressor in the normal adrenal cortex and in adrenocortical adenomas and carcinomas. Peri, A., Luciani, P., Conforti, B., Baglioni-Peri, S., Cioppi, F., Crescioli, C., Ferruzzi, P., Gelmini, S., Arnaldi, G., Nesi, G., Serio, M., Mantero, F., Mannelli, M. J. Clin. Endocrinol. Metab. (2001)
- Severe impairment of spermatogenesis in mice lacking the CREM gene. Blendy, J.A., Kaestner, K.H., Weinbauer, G.F., Nieschlag, E., Schütz, G. Nature (1996)
- Investigation of polymorphisms in the CREM gene in panic disorder. Hamilton, S.P., Slager, S.L., Mayo, D., Heiman, G.A., Klein, D.F., Hodge, S.E., Fyer, A.J., Weissman, M.M., Knowles, J.A. Am. J. Med. Genet. B Neuropsychiatr. Genet. (2004)
- Positive regulation of the cAMP-responsive activator CREM by the p70 S6 kinase: an alternative route to mitogen-induced gene expression. de Groot, R.P., Ballou, L.M., Sassone-Corsi, P. Cell (1994)
- CREM gene: use of alternative DNA-binding domains generates multiple antagonists of cAMP-induced transcription. Foulkes, N.S., Borrelli, E., Sassone-Corsi, P. Cell (1991)
- CBP-independent activation of CREM and CREB by the LIM-only protein ACT. Fimia, G.M., De Cesare, D., Sassone-Corsi, P. Nature (1999)
- DREAM-alphaCREM interaction via leucine-charged domains derepresses downstream regulatory element-dependent transcription. Ledo, F., Carrión, A.M., Link, W.A., Mellström, B., Naranjo, J.R. Mol. Cell. Biol. (2000)
- The role of inducible repressor proteins in the adrenergic induction of arylalkylamine-N-acetyltransferase and mitogen-activated protein kinase phosphatase-1 in rat pinealocytes. Ho, A.K., Terriff, D.L., Price, D.M., Wloka, M.T., Chik, C.L. Endocrinology (2007)
- Using economic analysis to evaluate the potential of multimodality therapy for elderly patients with locally advanced pancreatic cancer. Krzyzanowska, M.K., Earle, C.C., Kuntz, K.M., Weeks, J.C. Int. J. Radiat. Oncol. Biol. Phys. (2007)
- Identification and expression of a novel isoform of cAMP response element modulator in the human heart. Müller, F.U., Bokník, P., Knapp, J., Neumann, J., Vahlensieck, U., Oetjen, E., Scheld, H.H., Schmitz, W. FASEB J. (1998)
- Differential activation of viral and cellular promoters by human T-cell lymphotropic virus-1 tax and cAMP-responsive element modulator isoforms. Laurance, M.E., Kwok, R.P., Huang, M.S., Richards, J.P., Lundblad, J.R., Goodman, R.H. J. Biol. Chem. (1997)
- The dynamics of the transcriptional response to cyclic adenosine 3',5'-monophosphate: recurrent inducibility and refractory phase. Lamas, M., Sassone-Corsi, P. Mol. Endocrinol. (1997)
- The expanding family of CREB/CREM transcription factors that are involved with spermatogenesis. Don, J., Stelzer, G. Mol. Cell. Endocrinol. (2002)
- Round spermatids show normal testis-specific H1t but reduced cAMP-responsive element modulator and transition protein 1 expression in men with round-spermatid maturation arrest. Steger, K., Klonisch, T., Gavenis, K., Behr, R., Schaller, V., Drabent, B., Doenecke, D., Nieschlag, E., Bergmann, M., Weinbauer, G.F. J. Androl. (1999)
- cAMP-response element modulator-tau activates a distinct promoter element for the expression of the phospholipid hydroperoxide/sperm nucleus glutathione peroxidase gene. Tramer, F., Vetere, A., Martinelli, M., Paroni, F., Marsich, E., Boitani, C., Sandri, G., Panfili, E. Biochem. J. (2004)
- Human endometrial stromal cells express novel isoforms of the transcriptional modulator CREM and up-regulate ICER in the course of decidualization. Gellersen, B., Kempf, R., Telgmann, R. Mol. Endocrinol. (1997)
- Coupling signalling pathways to transcriptional control: nuclear factors responsive to cAMP. Tamai, K.T., Monaco, L., Nantel, F., Zazopoulos, E., Sassone-Corsi, P. Recent Prog. Horm. Res. (1997)
- Human CREM gene: evolutionary conservation, chromosomal localization, and inducibility of the transcript. Masquilier, D., Foulkes, N.S., Mattei, M.G., Sassone-Corsi, P. Cell Growth Differ. (1993)
- The functional versatility of CREM is determined by its modular structure. Laoide, B.M., Foulkes, N.S., Schlotter, F., Sassone-Corsi, P. EMBO J. (1993)
- An isoform of transcription factor CREM expressed during spermatogenesis lacks the phosphorylation domain and represses cAMP-induced transcription. Walker, W.H., Sanborn, B.M., Habener, J.F. Proc. Natl. Acad. Sci. U.S.A. (1994)
- The cyclic AMP response element modulator family regulates the insulin gene transcription by interacting with transcription factor IID. Inada, A., Someya, Y., Yamada, Y., Ihara, Y., Kubota, A., Ban, N., Watanabe, R., Tsuda, K., Seino, Y. J. Biol. Chem. (1999)
- Systemic lupus erythematosus serum IgG increases CREM binding to the IL-2 promoter and suppresses IL-2 production through CaMKIV. Juang, Y.T., Wang, Y., Solomou, E.E., Li, Y., Mawrin, C., Tenbrock, K., Kyttaris, V.C., Tsokos, G.C. J. Clin. Invest. (2005)
- Cyclic adenosine 5'-monophosphate response element modulator is responsible for the decreased expression of c-fos and activator protein-1 binding in T cells from patients with systemic lupus erythematosus. Kyttaris, V.C., Juang, Y.T., Tenbrock, K., Weinstein, A., Tsokos, G.C. J. Immunol. (2004)
- Role of transcriptional repressor ICER in cyclic AMP-mediated attenuation of cytokine gene expression in human thymocytes. Bodor, J., Habener, J.F. J. Biol. Chem. (1998)
- Activating transcription factor 1 and cyclic AMP response element modulator can modulate the activity of the immunoglobulin kappa 3' enhancer. Pongubala, J.M., Atchison, M.L. J. Biol. Chem. (1995)
- A positive feedback loop of phosphodiesterase 3 (PDE3) and inducible cAMP early repressor (ICER) leads to cardiomyocyte apoptosis. Ding, B., Abe, J., Wei, H., Xu, H., Che, W., Aizawa, T., Liu, W., Molina, C.A., Sadoshima, J., Blaxall, B.C., Berk, B.C., Yan, C. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target repressors of cyclic AMP-induced transcription for proteolysis. Pati, D., Meistrich, M.L., Plon, S.E. Mol. Cell. Biol. (1999)
- Loss of expression of the ubiquitous transcription factor cAMP response element-binding protein (CREB) and compensatory overexpression of the activator CREMtau in the human adrenocortical cancer cell line H295R. Groussin, L., Massias, J.F., Bertagna, X., Bertherat, J. J. Clin. Endocrinol. Metab. (2000)
- Genetic characterization of transactivation of the human T-cell leukemia virus type 1 promoter: Binding of Tax to Tax-responsive element 1 is mediated by the cyclic AMP-responsive members of the CREB/ATF family of transcription factors. Bantignies, F., Rousset, R., Desbois, C., Jalinot, P. Mol. Cell. Biol. (1996)
- Marmoset spermatogenesis: organizational similarities to the human. Millar, M.R., Sharpe, R.M., Weinbauer, G.F., Fraser, H.M., Saunders, P.T. Int. J. Androl. (2000)
- Identification and characterization of CKLiK, a novel granulocyte Ca(++)/calmodulin-dependent kinase. Verploegen, S., Lammers, J.W., Koenderman, L., Coffer, P.J. Blood (2000)
- Coupling cAMP signaling to transcription in the liver: pivotal role of CREB and CREM. Servillo, G., Della Fazia, M.A., Sassone-Corsi, P. Exp. Cell Res. (2002)