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Gene Review

GHSR  -  growth hormone secretagogue receptor

Gallus gallus

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High impact information on GHSR

  • These findings indicate that ghrelin acts as an anti-dipsogenic peptide through the GHS receptor in the chicken [1].
  • Chicken GHS-R gene is composed of two exons separated by an intron [2].
  • Two GHS-R mRNA species, cGHS-R1a and cGHS-R1a-variant (cGHS-R1aV) are generated by alternative splicing of a primary transcript. cGHS-R1a protein is predicted to have seven transmembrane domains by a high degree of amino acid sequence identity with mammalian and teleost homologs. cGHS-R1aV lacks the transmembrane-6 domain due to a 48 bp deletion [2].

Anatomical context of GHSR


Other interactions of GHSR

  • Expression of the gene encoding the receptor for ghrelin (growth hormone secretagogue receptor, GHS-R) and a variant form was detected in a variety of tissues collected from 3-week-old male broiler chickens possibly suggesting autocrine/paracrine effects [4].


  1. Central ghrelin acts as an anti-dipsogenic peptide in chicks. Tachibana, T., Kaiya, H., Denbow, D.M., Kangawa, K., Furuse, M. Neurosci. Lett. (2006) [Pubmed]
  2. Molecular characterization of chicken growth hormone secretagogue receptor gene. Tanaka, M., Miyazaki, T., Yamamoto, I., Nakai, N., Ohta, Y., Tsushima, N., Wakita, M., Shimada, K. Gen. Comp. Endocrinol. (2003) [Pubmed]
  3. Existence of ghrelin-immunopositive and -expressing cells in the proventriculus of the hatching and adult chicken. Wada, R., Sakata, I., Kaiya, H., Nakamura, K., Hayashi, Y., Kangawa, K., Sakai, T. Regul. Pept. (2003) [Pubmed]
  4. Characterization of turkey and chicken ghrelin genes, and regulation of ghrelin and ghrelin receptor mRNA levels in broiler chickens. Richards, M.P., Poch, S.M., McMurtry, J.P. Gen. Comp. Endocrinol. (2006) [Pubmed]
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