Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

Prosalpha4T2 - Proteasome alpha4 subunit, Testis-specific 2

Drosophila melanogaster

Synonyms: CG4569, Dmel\CG4569, Pros28.1B, Proteasome subunit alpha type-7-1B, Testis-specific alpha4-t2 proteasome subunit, ...

Belote, J.M. et al., Yuan, X. et al., Torgerson, D.G. et al.

Torgerson, Singh, Belote, Miller, Smyth,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Pros28.1B

Our data suggest that following gene duplication, the alpha4-t1 gene experienced relaxed selective constraints, whereas the alpha4-t2 gene experienced positive selection acting on several codons [1].
The Pros28.1B gene has two introns, located in exactly analogous positions as the two introns in Pros28.1, while the Pros28.1A gene lacks introns [2].

Biological context of Pros28.1B

Pros28.1A expression is first detected at the primary spermatocyte stage and persists into the spermatid elongation phase of spermiogenesis, while Pros28.1B expression is prominent only during spermatid elongation [2].

Anatomical context of Pros28.1B

Previous work had shown that there exist alternative isoforms of the Drosophila melanogaster alpha4-type subunit, encoded by two distinct genes, alpha4t1_dm and alpha4t2_dm, and that these are expressed exclusively in the germline of the testes [3].

Other interactions of Pros28.1B

We isolated the D. virilis orthologs of the somatically expressed gene, alpha4_dm, and the testes-specific gene, alpha4t2_dm [3].

References

Rapid evolution through gene duplication and subfunctionalization of the testes-specific alpha4 proteasome subunits in Drosophila. Torgerson, D.G., Singh, R.S. Genetics (2004) [Pubmed]
Duplicated proteasome subunit genes in Drosophila melanogaster encoding testes-specific isoforms. Yuan, X., Miller, M., Belote, J.M. Genetics (1996) [Pubmed]
Evolutionary conservation of a testes-specific proteasome subunit gene in Drosophila. Belote, J.M., Miller, M., Smyth, K.A. Gene (1998) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.