High impact information on Start1

• Vice versa, the expression of Start1 itself seems to depend on ecdysone, as in the ecdysone-deficient mutant ecd-1, Start1 expression is severely reduced [1].
• The Drosophila gene Start1: a putative cholesterol transporter and key regulator of ecdysteroid synthesis [1].
• Transcripts of Start1 are detectable in embryonic ring gland progenitor cells and are abundant in prothoracic glands of larvae showing wave-like expression during larval stages [1].

Analytical, diagnostic and therapeutic context of Start1

• Whereas RT-PCR data indicate that Start1 is expressed ubiquitously, RNA in situ hybridizations demonstrate its overexpression in prothoracic gland cells, where ecdysteroids are synthesized from cholesterol [1].

References