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Gene Review

ecd  -  ecdysoneless

Drosophila melanogaster

Synonyms: CG5714, Dmel\CG5714, Protein SGT1 homolog ecdysoneless, ecd-1, ecd1, ...
 
 
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High impact information on ecd

  • Vice versa, the expression of Start1 itself seems to depend on ecdysone, as in the ecdysone-deficient mutant ecd-1, Start1 expression is severely reduced [1].
  • The fat bodies were isolated from ecdysterone-deficient larvae of the temperature-sensitive mutant ecd1, which were shifted from the permissive to the restrictive temperature either at the beginning of the third instar for the detection of LSP-2 induction or several hours later for the detection of P1 induction [2].
  • To obtain evidence that ecdysterone induces the appearance of this mRNA we made use of the temperature-sensitive ecd1 mutant [3].
  • Cell-autonomous roles of the ecdysoneless gene in Drosophila development and oogenesis [4].
  • Genetic disruption both of the ecdysone signal in vivo with the ecdysoneless1 (ecd1) mutant and of ecdysone response with a Broad-Complex mutant result in disruption of morphogenetic furrow progression [5].
 

Biological context of ecd

 

Anatomical context of ecd

 

Associations of ecd with chemical compounds

  • The Drosophila melanogaster ecd1 mutation causes a severe temperature-sensitive deficiency in the titre of the steroid hormone ecdysone [9].
  • These data suggest that the defect in ecd1 tissue-mediated ecdysteroidogenesis does not involve a "hit" on any of the enzymes involved in either the 7,8-dehydrogenation of C or 25C or in the subsequent oxidation of 7d25C or 7dC to ecdysteroid [10].
  • Differential incorporation of cholesterol and cholesterol derivatives into ecdysteroids by the larval ring glands and adult ovaries of Drosophila melanogaster: a putative explanation for the l(3)ecd1 mutation [10].
 

Other interactions of ecd

  • Ance protein and mRNA were not detected in imaginal discs from wandering larvae of flies homozygous for the ecd ( 1 ) allele, a temperature-sensitive ecdysone-less mutant, suggesting that Ance expression is ecdysteroid-dependent [11].
  • In mutant l(3)ecdysone-1ts (ecd-1) larvae, the normal peak of Gld mRNA late in the third instar is not expressed [12].
  • Conversely, the normal decrease in Adh mRNA at this stage fails to occur in ecd-1 [12].

References

  1. The Drosophila gene Start1: a putative cholesterol transporter and key regulator of ecdysteroid synthesis. Roth, G.E., Gierl, M.S., Vollborn, L., Meise, M., Lintermann, R., Korge, G. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  2. Selective gene expression induced by ecdysterone in cultured fat bodies of Drosophila. Nakanishi, Y., Garen, A. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  3. Induction of translatable mRNA for dopa decarboxylase in Drosophila: an early response to ecdysterone. Kraminsky, G.P., Clark, W.C., Estelle, M.A., Gietz, R.D., Sage, B.A., O'Connor, J.D., Hodgetts, R.B. Proc. Natl. Acad. Sci. U.S.A. (1980) [Pubmed]
  4. Cell-autonomous roles of the ecdysoneless gene in Drosophila development and oogenesis. Gaziova, I., Bonnette, P.C., Henrich, V.C., Jindra, M. Development (2004) [Pubmed]
  5. Ecdysone pathway is required for furrow progression in the developing Drosophila eye. Brennan, C.A., Ashburner, M., Moses, K. Development (1998) [Pubmed]
  6. Developmental requirements for the ecdysoneless (ecd) locus in Drosophila melanogaster. Henrich, V.C., Livingston, L., Gilbert, L.I. Dev. Genet. (1993) [Pubmed]
  7. The genetics of the Dras3-Roughened-ecdysoneless chromosomal region (62B3-4 to 62D3-4) in Drosophila melanogaster: analysis of recessive lethal mutations. Sliter, T.J., Henrich, V.C., Tucker, R.L., Gilbert, L.I. Genetics (1989) [Pubmed]
  8. Effects of the ecdysoneless mutant on synaptic efficacy and structure at the neuromuscular junction in Drosophila larvae during normal and prolonged development. Li, H., Cooper, R.L. Neuroscience (2001) [Pubmed]
  9. Effect of ecd1 mutation on the expression of genes mapped at the Drosophila melanogaster 3C11-12 intermoult puff. Furia, M., D'Avino, P.P., Digilio, F.A., Crispi, S., Giordano, E., Polito, L.C. Genet. Res. (1992) [Pubmed]
  10. Differential incorporation of cholesterol and cholesterol derivatives into ecdysteroids by the larval ring glands and adult ovaries of Drosophila melanogaster: a putative explanation for the l(3)ecd1 mutation. Warren, J.T., Bachmann, J.S., Dai, J.D., Gilbert, L.I. Insect Biochem. Mol. Biol. (1996) [Pubmed]
  11. Ance, a Drosophila angiotensin-converting enzyme homologue, is expressed in imaginal cells during metamorphosis and is regulated by the steroid, 20-hydroxyecdysone. Siviter, R.J., Taylor, C.A., Cottam, D.M., Denton, A., Dani, M.P., Milner, M.J., Shirras, A.D., Isaac, R.E. Biochem. J. (2002) [Pubmed]
  12. Ecdysteroid regulation of glucose dehydrogenase and alcohol dehydrogenase gene expression in Drosophila melanogaster. Murtha, M.T., Cavener, D.R. Dev. Biol. (1989) [Pubmed]
 
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