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Gene Review

SAB1322c  -  glycosyltransferase

Staphylococcus aureus RF122

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Disease relevance of SAB1322c


High impact information on SAB1322c

  • CrtQ, a glycosyltransferase, esterifies glucose at the C(1)'' position with the carboxyl group of 4,4'-diaponeurosporenic acid to yield glycosyl 4,4'-diaponeurosporenoate; this compound was the major product in the clone expressing crtPQMN [3].
  • To identify the glycosyltransferase partner(s) of PBP5, combinations of deletions were introduced in all three class A PBP genes of E. faecalis JH2-2 (ponA, pbpF, and pbpZ) [4].
  • As the E. faecalis chromosome does not contain any additional glycosyltransferase-related genes, these observations indicate that glycan chain polymerization in the triple mutant is performed by a novel type of glycosyltransferase [4].
  • The latter enzyme was not inhibited by moenomycin, since deletion of the three class A PBP genes led to high-level resistance to this glycosyltransferase inhibitor [4].
  • Peptidoglycan polymerization complexes contain multimodular penicillin-binding proteins (PBP) of classes A and B that associate a conserved C-terminal transpeptidase module to an N-terminal glycosyltransferase or morphogenesis module, respectively [4].


  1. Topology of nucleotide-sugar:dolichyl phosphate glycosyltransferases involved in the dolichol pathway for protein glycosylation in native rat liver microsomes. Bossuyt, X., Blanckaert, N. Biochem. J. (1993) [Pubmed]
  2. Identification and characterization of a monofunctional glycosyltransferase from Staphylococcus aureus. Wang, Q.M., Peery, R.B., Johnson, R.B., Alborn, W.E., Yeh, W.K., Skatrud, P.L. J. Bacteriol. (2001) [Pubmed]
  3. Structure and biosynthesis of staphyloxanthin from Staphylococcus aureus. Pelz, A., Wieland, K.P., Putzbach, K., Hentschel, P., Albert, K., Götz, F. J. Biol. Chem. (2005) [Pubmed]
  4. Role of class A penicillin-binding proteins in PBP5-mediated beta-lactam resistance in Enterococcus faecalis. Arbeloa, A., Segal, H., Hugonnet, J.E., Josseaume, N., Dubost, L., Brouard, J.P., Gutmann, L., Mengin-Lecreulx, D., Arthur, M. J. Bacteriol. (2004) [Pubmed]
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