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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Psa  -  Puromycin sensitive aminopeptidase

Drosophila melanogaster

Synonyms: CG1009, Dmel\CG1009, PSA, dPSA, dPsa, ...
 
 
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Disease relevance of Psa

  • A genomic screen for modifiers of tauopathy identifies puromycin-sensitive aminopeptidase as an inhibitor of tau-induced neurodegeneration [1].
 

High impact information on Psa

  • We used a cross species functional genomic approach to analyze gene expression in multiple brain regions in mouse, in parallel with validation in Drosophila, to identify tau modifiers, including the highly conserved protein puromycin-sensitive aminopeptidase (PSA/Npepps) [1].
  • Abstract. The Drosophila genome contains a single orthologue of mammalian puromycin-sensitive aminopeptidases, dPsa [2].
 

Biological context of Psa

  • By screening the Drosophila genome we found 43 predicted aminopeptidases and generated a phylogenetic tree of aminopeptidases related to dPsa by sequence [2].

References

  1. A genomic screen for modifiers of tauopathy identifies puromycin-sensitive aminopeptidase as an inhibitor of tau-induced neurodegeneration. Karsten, S.L., Sang, T.K., Gehman, L.T., Chatterjee, S., Liu, J., Lawless, G.M., Sengupta, S., Berry, R.W., Pomakian, J., Oh, H.S., Schulz, C., Hui, K.S., Wiedau-Pazos, M., Vinters, H.V., Binder, L.I., Geschwind, D.H., Jackson, G.R. Neuron (2006) [Pubmed]
  2. Genetic analysis of dPsa, the Drosophila orthologue of puromycin-sensitive aminopeptidase, suggests redundancy of aminopeptidases. Schulz, C., Perezgasga, L., Fuller, M.T. Dev. Genes Evol. (2001) [Pubmed]
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