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Gene Review

cooA  -  CS1 fimbrial subunit A precursor

Escherichia coli

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Disease relevance of cooA


High impact information on cooA

  • Gain-of-function CooA variants were isolated in E. coli following mutagenesis of the portion of cooA encoding the effector-binding domain [2].
  • We have identified a gene, cooB, which lies directly upstream of cooA, the gene that encodes the major structural CS1 protein [3].
  • However, the cooB-1 strain with cooA in trans does not cause haemagglutination of bovine erythrocytes (the model system used to assay adherence mediated by coli surface antigen 1 (CS1) pili).(ABSTRACT TRUNCATED AT 250 WORDS)[3]
  • Hybridization showed that the ETEC strain from which it was cloned carried cooA on a plasmid different from the one encoding its positive regulator, rns [4].
  • When the 2.5-kb region was sequenced, one open reading frame, designated cooA, predicted a product showing similarity to members of the cyclic AMP receptor protein (CRP) family of transcriptional regulators [5].

Chemical compound and disease context of cooA


Biological context of cooA

  • The nucleotide sequence of the subunit gene (csoA), encoding a protein of 171 amino acids, was determined [7].
  • The insertion of a drug resistance cassette into cooA resulted in a mutant that could not grow utilizing CO as an energy source [5].

Anatomical context of cooA

  • To test function, we examined cooA mutants for the ability to agglutinate bovine erythrocytes [8].


  1. Horizontal transfer of CS1 pilin genes of enterotoxigenic Escherichia coli. Froehlich, B., Holtzapple, E., Read, T.D., Scott, J.R. J. Bacteriol. (2004) [Pubmed]
  2. Mapping CooA.RNA polymerase interactions. Identification of activating regions 2 and 3 in CooA, the co-sensing transcriptional activator. Leduc, J., Thorsteinsson, M.V., Gaal, T., Roberts, G.P. J. Biol. Chem. (2001) [Pubmed]
  3. CooB is required for assembly but not transport of CS1 pilin. Scott, J.R., Wakefield, J.C., Russell, P.W., Orndorff, P.E., Froehlich, B.J. Mol. Microbiol. (1992) [Pubmed]
  4. Gene encoding the major subunit of CS1 pili of human enterotoxigenic Escherichia coli. Perez-Casal, J., Swartley, J.S., Scott, J.R. Infect. Immun. (1990) [Pubmed]
  5. Carbon monoxide-induced activation of gene expression in Rhodospirillum rubrum requires the product of cooA, a member of the cyclic AMP receptor protein family of transcriptional regulators. Shelver, D., Kerby, R.L., He, Y., Roberts, G.P. J. Bacteriol. (1995) [Pubmed]
  6. A novel heme protein that acts as a carbon monoxide-dependent transcriptional activator in Rhodospirillum rubrum. Aono, S., Nakajima, H., Saito, K., Okada, M. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
  7. Analysis of the first two genes of the CS1 fimbrial operon in human enterotoxigenic Escherichia coli of serotype 0139:H28. Jordi, B.J., van Vliet, A.H., Willshaw, G.A., van der Zeijst, B.A., Gaastra, W. FEMS Microbiol. Lett. (1991) [Pubmed]
  8. Assembly of CS1 pili: the role of specific residues of the major pilin, CooA. Starks, A.M., Froehlich, B.J., Jones, T.N., Scott, J.R. J. Bacteriol. (2006) [Pubmed]
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