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Gene Review

Cdc27  -  Cell division cycle 27 ortholog

Drosophila melanogaster

Synonyms: APC3, Apc3, CDC27, CDC27Dm, CG8610, ...
 
 
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High impact information on Cdc27

  • Furthermore, analysis of mitotic progression in cells carrying mutations for cdc27 and bub3 suggest the existence of differentially activated APC/C complexes [1].
  • The metaphase-like arrest of mks mutants cannot be overcome by mutations in the spindle integrity checkpoint gene bub1, confirming this surveillance pathway has to operate through the APC/C [2].
  • However, mutations in the twins/aar gene, which encodes the 55kDa regulatory subunit of PP2A, do suppress the mks metaphase arrest and so permit an alternative means of initiating anaphase [2].
  • Neuroblasts from third-larval-instar mks mutants arrest mitosis in a metaphase-like state but show some separation of sister chromatids [2].
  • Moreover, reducing the levels of Cdc16 or Cdc27 by >90% in tissue culture cells led to a transient mitotic arrest that was both biochemically and morphologically distinct [3].

References

 
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