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Gene Review

CDC27  -  cell division cycle 27

Homo sapiens

Synonyms: ANAPC3, APC3, Anaphase-promoting complex subunit 3, CDC27 homolog, CDC27Hs, ...
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Disease relevance of CDC27


High impact information on CDC27


Biological context of CDC27


Anatomical context of CDC27


Associations of CDC27 with chemical compounds


Physical interactions of CDC27

  • We further provide biochemical evidence that the C-terminus of APC10 binds to CDC27/APC3, an APC subunit that contains multiple tetratrico peptide repeats [10].

Regulatory relationships of CDC27

  • Therefore, APC 3 x 15 domain plays a positive role in the control of transcriptional activity of beta-catenin-TCF-4 and can contribute to explain the role of the truncated forms of APC in colon tumorigenesis [11].

Other interactions of CDC27

  • The estimated distance between ITGB3 and human CDC27 is less than 600 kb [1].
  • In the present report, we demonstrate that the inhibitory association between Mad2 and the APC component Cdc27 also takes place transiently during the early stages of a normal mitosis and is lost before mitotic exit [12].
  • Consistent with the notion that Tax activates APC(Cdc20) directly, Tax is found to coimmunoprecipitate with Cdc20 and Cdc27/APC3 [13].
  • Here we show by a combination of two-hybrid analysis and in vitro binding that PP5 interacts with CDC16 and CDC27, two subunits of the anaphase-promoting complex [9].
  • Moreover, previous binding of APC 3 x 15 facilitates the association of beta-catenin to the TATA box-associated protein [11].

Analytical, diagnostic and therapeutic context of CDC27


  1. Localization of the human homolog of the yeast cell division control 27 gene (CDC27) proximal to ITGB3 on human chromosome 17q21.3. Ho, P.P., Couch, F.J., Brody, L.C., Abel, K.J., Boehnke, M., Shearon, T.H., Chandrasekharappa, S.C., Collins, F.S., Weber, B.L. Somat. Cell Mol. Genet. (1995) [Pubmed]
  2. Efficient manipulation of the human adenovirus genome as an infectious yeast artificial chromosome clone. Ketner, G., Spencer, F., Tugendreich, S., Connelly, C., Hieter, P. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  3. CDC27Hs colocalizes with CDC16Hs to the centrosome and mitotic spindle and is essential for the metaphase to anaphase transition. Tugendreich, S., Tomkiel, J., Earnshaw, W., Hieter, P. Cell (1995) [Pubmed]
  4. Cloning genes encoding MHC class II-restricted antigens: mutated CDC27 as a tumor antigen. Wang, R.F., Wang, X., Atwood, A.C., Topalian, S.L., Rosenberg, S.A. Science (1999) [Pubmed]
  5. The Arabidopsis HOBBIT gene encodes a CDC27 homolog that links the plant cell cycle to progression of cell differentiation. Blilou, I., Frugier, F., Folmer, S., Serralbo, O., Willemsen, V., Wolkenfelt, H., Eloy, N.B., Ferreira, P.C., Weisbeek, P., Scheres, B. Genes Dev. (2002) [Pubmed]
  6. Linking yeast genetics to mammalian genomes: identification and mapping of the human homolog of CDC27 via the expressed sequence tag (EST) data base. Tugendreich, S., Boguski, M.S., Seldin, M.S., Hieter, P. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  7. Identification of a human homologue of yeast nuc2 which interacts with the retinoblastoma protein in a specific manner. Chen, P.L., Ueng, Y.C., Durfee, T., Chen, K.C., Yang-Feng, T., Lee, W.H. Cell Growth Differ. (1995) [Pubmed]
  8. The dephosphorylated form of the anaphase-promoting complex protein Cdc27/Apc3 concentrates on kinetochores and chromosome arms in mitosis. Topper, L.M., Campbell, M.S., Tugendreich, S., Daum, J.R., Burke, D.J., Hieter, P., Gorbsky, G.J. Cell Cycle (2002) [Pubmed]
  9. The serine/threonine phosphatase PP5 interacts with CDC16 and CDC27, two tetratricopeptide repeat-containing subunits of the anaphase-promoting complex. Ollendorff, V., Donoghue, D.J. J. Biol. Chem. (1997) [Pubmed]
  10. Crystal structure of the APC10/DOC1 subunit of the human anaphase-promoting complex. Wendt, K.S., Vodermaier, H.C., Jacob, U., Gieffers, C., Gmachl, M., Peters, J.M., Huber, R., Sondermann, P. Nat. Struct. Biol. (2001) [Pubmed]
  11. APC 3 x 15 beta-catenin-binding domain potentiates beta-catenin association to TBP and upregulates TCF-4 transcriptional activity. Roura, S., Martínez, D., Piedra, J., Miravet, S., García de Herreros, A., Duñach, M. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  12. Mad2 transiently associates with an APC/p55Cdc complex during mitosis. Wassmann, K., Benezra, R. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  13. HTLV-I Tax directly binds the Cdc20-associated anaphase-promoting complex and activates it ahead of schedule. Liu, B., Hong, S., Tang, Z., Yu, H., Giam, C.Z. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  14. Mapping and mutation of the conserved DNA polymerase interaction motif (DPIM) located in the C-terminal domain of fission yeast DNA polymerase delta subunit Cdc27. Gray, F.C., Pohler, J.R., Warbrick, E., MacNeill, S.A. BMC Mol. Biol. (2004) [Pubmed]
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