Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

tws - twins

Drosophila melanogaster

Synonyms: 1466/06, 2414, B/PR55, CG6235, DPR55, ...

Deak, P. et al., Mayer-Jaekel, R.E. et al., Williams, B.C. et al., Gomes, R. et al., Bajpai, R. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on tws

The gene encoding the Drosophila protein phosphatase 2A 55 kd regulatory subunit (PR55) is located at 85F and directs the synthesis of differentially spliced transcripts [1].
In tws(-) wing discs both short- and long-range targets of Wingless morphogen are downregulated [2].
However, mutations in the twins/aar gene, which encodes the 55kDa regulatory subunit of PP2A, do suppress the mks metaphase arrest and so permit an alternative means of initiating anaphase [3].
(c) The localization of zw10 protein is altered by two mitotic mutations, rough deal and abnormal anaphase resolution, that specifically disrupt anaphase [4].
Abnormal anaphase resolution (aar): a locus required for progression through mitosis in Drosophila [5].

References

The 55 kd regulatory subunit of Drosophila protein phosphatase 2A is required for anaphase. Mayer-Jaekel, R.E., Ohkura, H., Gomes, R., Sunkel, C.E., Baumgartner, S., Hemmings, B.A., Glover, D.M. Cell (1993) [Pubmed]
Drosophila Twins regulates Armadillo levels in response to Wg/Wnt signal. Bajpai, R., Makhijani, K., Rao, P.R., Shashidhara, L.S. Development (2004) [Pubmed]
Mutations in mákos, a Drosophila gene encoding the Cdc27 subunit of the anaphase promoting complex, enhance centrosomal defects in polo and are suppressed by mutations in twins/aar, which encodes a regulatory subunit of PP2A. Deak, P., Donaldson, M., Glover, D.M. J. Cell. Sci. (2003) [Pubmed]
Determinants of Drosophila zw10 protein localization and function. Williams, B.C., Goldberg, M.L. J. Cell. Sci. (1994) [Pubmed]
Abnormal anaphase resolution (aar): a locus required for progression through mitosis in Drosophila. Gomes, R., Karess, R.E., Ohkura, H., Glover, D.M., Sunkel, C.E. J. Cell. Sci. (1993) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

AgaP_AGAP004502	Anopheles gambiae str. PEST
B ALPHA	Arabidopsis thaliana
ATB BETA	Arabidopsis thaliana
AGOS_AFR195W	Ashbya gossypii ATCC 10895
sur-6	Caenorhabditis elegans
PPP2R2D	Canis lupus familiaris
ppp2r2bb	Danio rerio
PPP2R2D	Gallus gallus
PPP2R2D	Homo sapiens
KLLA0F09053g	Kluyveromyces lactis NRRL Y-1140
MGG_05637	Magnaporthe oryzae 70-15
Ppp2r2d	Mus musculus
NCU09377	Neurospora crassa OR74A
Os06g0563300	Oryza sativa Japonica Group
Os02g0224200	Oryza sativa Japonica Group
Ppp2r2d	Rattus norvegicus
CDC55	Saccharomyces cerevisiae S288c
pab1	Schizosaccharomyces pombe 972h-
ppp2r2d	Xenopus (Silurana) tropicalis

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

Editor

Share