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Gene Review:

ie2 - IE2

Hyphantria cunea nucleopolyhedrovirus

Theilmann, D.A. et al., Wu, Y. et al.

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Disease relevance of ie2

Plasmids carrying the complete ie-2 and pe38 genes, the ie-1 gene upstream region, or a variety of baculovirus genes including 11 early promoter regions were also able to replicate in virus-infected cells, suggesting that early viral promoter sequences could also function as putative origins of replication [1].
An enhancer element was identified in the virus Orgyia pseudotsugata multicapsid nuclear polyhedrosis virus (OpMNPV) that is located adjacent to the 3' end of the IE-2 gene and 5' to an open reading frame that codes for a predicted protein that has 37% homology to the AcMNPV PE-38 gene [2].

High impact information on ie2

Tandemly repeated sequence at the 3' end of the IE-2 gene of the baculovirus Orgyia pseudotsugata multicapsid nuclear polyhedrosis virus is an enhancer element [2].
The OpE sequences were shown to increase gene expression from the Autographa californica MNPV delayed early p39 promoter independently of position or orientation, and were also shown to increase expression from the promoter of the OpMNPV immediate early gene, IE-2 [2].

References

Initiation of baculovirus DNA replication: early promoter regions can function as infection-dependent replicating sequences in a plasmid-based replication assay. Wu, Y., Carstens, E.B. J. Virol. (1996) [Pubmed]
Tandemly repeated sequence at the 3' end of the IE-2 gene of the baculovirus Orgyia pseudotsugata multicapsid nuclear polyhedrosis virus is an enhancer element. Theilmann, D.A., Stewart, S. Virology (1992) [Pubmed]

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