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Gene Review

rt  -  rotated abdomen

Drosophila melanogaster

Synonyms: CG6097, DPOMT1, Dmel\CG6097, Dolichyl-phosphate-mannose--protein mannosyltransferase 1, POMT1, ...
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High impact information on rt

  • Moreover, dPOMT2 interacted genetically with dPOMT1, suggesting that the dPOMTs function in collaboration with each other in vivo [1].
  • The previously reported mutant phenotype of the rt gene includes a clockwise rotation of the abdomen and defects in embryonic muscle development [2].
  • In situ hybridization analysis showed that both genes have essentially overlapping patterns of expression throughout most of embryogenesis (stages 8-17), while only the rt transcript is present at early embryonic stages (5 and 6), suggesting its maternal origin [2].
  • The twisted alleles represent a complementation group of recessive mutations that, similar to the rt mutants, exhibit a clockwise abdomen rotation phenotype [2].

Biological context of rt

  • Drosophila POMT2 (dPOMT2) RNAi mutant flies showed a "twisted abdomen phenotype," in which the abdomen is twisted 30-60 degrees , similar to the dPOMT1 mutant [1].

Other interactions of rt


Analytical, diagnostic and therapeutic context of rt

  • We therefore carried out PCR using primers which hybridize to the rt gene of RIRE3, and total genomic DNA from various monocot and dicot plants as templates, and found that a family of RIRE3 elements was present in all plants tested [3].


  1. The twisted abdomen phenotype of Drosophila POMT1 and POMT2 mutants coincides with their heterophilic protein O-mannosyltransferase activity. Ichimiya, T., Manya, H., Ohmae, Y., Yoshida, H., Takahashi, K., Ueda, R., Endo, T., Nishihara, S. J. Biol. Chem. (2004) [Pubmed]
  2. The twisted gene encodes Drosophila protein O-mannosyltransferase 2 and genetically interacts with the rotated abdomen gene encoding Drosophila protein O-mannosyltransferase 1. Lyalin, D., Koles, K., Roosendaal, S.D., Repnikova, E., Van Wechel, L., Panin, V.M. Genetics (2006) [Pubmed]
  3. Identification and characterization of novel retrotransposons of the gypsy type in rice. Kumekawa, N., Ohtsubo, H., Horiuchi, T., Ohtsubo, E. Mol. Gen. Genet. (1999) [Pubmed]
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