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Gene Review

PMT4  -  Pmt4p

Saccharomyces cerevisiae S288c

Synonyms: Dolichyl-phosphate-mannose--protein mannosyltransferase 4, J2176, YJR143C
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High impact information on PMT4

  • O-Glycosylation of Axl2/Bud10p by Pmt4p is required for its stability, localization, and function in daughter cells [1].
  • PMT4 encodes a protein mannosyl transferase (pmt) required for O-linked glycosylation of some secretory and cell surface proteins (Immervoll, T., M. Gentzsch, and W. Tanner. 1995. Yeast. 11:1345-1351) [1].
  • We found that a and alpha mutants defective in the previously identified PMT4 gene exhibit unipolar, rather than axial budding: mother cells choose axial bud sites, but daughter cells do not [1].
  • We demonstrate that Axl2/Bud10p, which is required for the axial budding pattern, is an O-linked glycoprotein and is incompletely glycosylated, unstable, and mislocalized in cells lacking PMT4 [1].
  • In cells lacking PMT4, encoding a mannosyltransferase involved in the initial step of O-glycosylation, Fus1p was not glycosylated and accumulated in late Golgi structures [2].

Biological context of PMT4


Other interactions of PMT4

  • Northern blot analysis showed a single mRNA transcript of PMT3 and PMT4 of 2.8 kb [3].
  • Overexpression of AXL2 can partially restore proper bud-site selection to pmt4 mutants [1].

Analytical, diagnostic and therapeutic context of PMT4


  1. O-Glycosylation of Axl2/Bud10p by Pmt4p is required for its stability, localization, and function in daughter cells. Sanders, S.L., Gentzsch, M., Tanner, W., Herskowitz, I. J. Cell Biol. (1999) [Pubmed]
  2. O-glycosylation as a sorting determinant for cell surface delivery in yeast. Proszynski, T.J., Simons, K., Bagnat, M. Mol. Biol. Cell (2004) [Pubmed]
  3. PMT3 and PMT4, two new members of the protein-O-mannosyltransferase gene family of Saccharomyces cerevisiae. Immervoll, T., Gentzsch, M., Tanner, W. Yeast (1995) [Pubmed]
  4. Members of the evolutionarily conserved PMT family of protein O-mannosyltransferases form distinct protein complexes among themselves. Girrbach, V., Strahl, S. J. Biol. Chem. (2003) [Pubmed]
  5. Characterization of O-mannosyltransferase family in Schizosaccharomyces pombe. Tanaka, N., Fujita, Y., Suzuki, S., Morishita, M., Giga-Hama, Y., Shimoda, C., Takegawa, K. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  6. cDNA encoding protein O-mannosyltransferase from the filamentous fungus Trichoderma reesei; functional equivalence to Saccharomyces cerevisiae PMT2. Zakrzewska, A., Migdalski, A., Saloheimo, M., Penttila, M.E., Palamarczyk, G., Kruszewska, J.S. Curr. Genet. (2003) [Pubmed]
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