High impact information on ara

• We provide evidence for the existence of this prepattern by identifying two of its factors, Araucan and Caupolican [1].
• It is known that the homeobox genes of the Iroquois complex (Iro-C) define the notum territory and that the distal limit of the Iro-C expression domain demarks the boundary between the notum and the wing hinge [2].
• The homeobox gene iroquois (iro) is expressed in the LAT region [3].
• During wing development, Hh also has morphogen-like Dpp-independent functions, controlling the morphogenesis of the central part of the wing through the activation of the evolutionarily conserved transcription factors encoded by the iroquois and collier genes [4].
• In support of this, we present sequence analyses that implicate genes of the iroquois Complex (Iro-C) and engrailed as additional targets of K box-mediated regulation [5].

Biological context of ara

• In the present paper, we report the identification of a novel member of the Iroquois gene family, Irx5, that shows a restricted spatio/temporal expression during early mouse embryogenesis, distinct from the expression of Irx1-3 [6].

Anatomical context of ara

• iroquois: a prepattern gene that controls the formation of bristles on the thorax of Drosophila [7].

Regulatory relationships of ara

• The iroquois complex controls the somatotopy of Drosophila notum mechanosensory projections [8].

Other interactions of ara

• Thus, ara and caup integrate the inputs of genes effecting the primary subdivisions of the wing disc into compartments to define two smaller territories [9].
• In addition, we show that the iroquois-complex genes are required for dorsal head development antagonizing the function of homothorax in this region of the disc [10].

Analytical, diagnostic and therapeutic context of ara

• An extensive sequence analysis of 20 Iroquois-like genes from seven organisms reveals a high conservation of the homeodomain [6].

References