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Gene Review

DBI  -  diazepam binding inhibitor (GABA receptor...

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High impact information on DBI

  • The fast one-step folding mechanism of ACBP has been shown to be a feature that seems to be maintained throughout evolution despite numerous differences in sequence and even dramatic differences in folding kinetics and protein stability [1].
  • A number of differently bioactive fragments with separate processings and tissue distributions have been observed, suggesting multiple functions of DBI and its sub-segments [2].


  1. Fast and one-step folding of closely and distantly related homologous proteins of a four-helix bundle family. Kragelund, B.B., Højrup, P., Jensen, M.S., Schjerling, C.K., Juul, E., Knudsen, J., Poulsen, F.M. J. Mol. Biol. (1996) [Pubmed]
  2. Full-length and N-terminally truncated chicken intestinal diazepam-binding inhibitor. Purification, structural characterization and influence on insulin release. Chen, Z.W., Bergman, T., Jörnvall, H., Bonetto, V., Norberg, A., Mutt, V., Longone, P., Costa, E., Efendic, S., Ostenson, C.G. Regul. Pept. (1997) [Pubmed]
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