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Gene Review

Dbi  -  diazepam binding inhibitor (GABA receptor...

Rattus norvegicus

Synonyms: ACBP, Acbp, Acoabp3, Acyl-CoA-binding protein, DBI, ...
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Disease relevance of Dbi


Psychiatry related information on Dbi


High impact information on Dbi


Chemical compound and disease context of Dbi


Biological context of Dbi


Anatomical context of Dbi

  • Here we confirm a previous observation that ACBP expression in rodent liver is down-regulated by fasting, and we show that insulin but not glucose is the inducer of ACBP expression in primary rat hepatocytes [18].
  • These findings provide evidence that C6-2B cells exhibit a significant steroidogenic activity which resembles that found in peripheral endocrine organs and they suggest that MDRs and DBI are involved in the regulation of glial cell steroidogenesis [2].
  • The steroidogenic capability of this cell line and the regulation of pregnenolone production by 4'-chlorodiazepam (4'CD), a specific ligand for the mitochondrial diazepam binding inhibitor (DBI) receptor (MDR), were investigated [19].
  • Diazepam-binding inhibitor (DBI)-processing products, acting at the mitochondrial DBI receptor, mediate adrenocorticotropic hormone-induced steroidogenesis in rat adrenal gland [20].
  • Both the content of DBI and DBI mRNA increased in the cerebellum and cerebral cortex but failed to change in the hippocampus and striatum of rats receiving this protracted benzodiazepine treatment [21].

Associations of Dbi with chemical compounds

  • In addition to high levels of mRNA in various brain regions, RNA blot analysis reveals an abundance of diazepam binding inhibitor mRNA in many peripheral organs (e.g., testes, kidney, liver, and heart) that are known to be rich in peripheral benzodiazepine recognition sites [1].
  • Diazepam binding inhibitor (DBI) is a 10-kDa polypeptide that regulates mitochondrial steroidogenesis, glucose-induced insulin secretion, metabolism of acyl-CoA esters, and the action of gamma-aminobutyrate on GABAA receptors [15].
  • Isolation and characterization of a rat brain triakontatetraneuropeptide, a posttranslational product of diazepam binding inhibitor: specific action at the Ro 5-4864 recognition site [16].
  • By binding with high affinity to the MDR, DBI and one of its processing products--DBI-(17-50)--regulate pregnenolone synthesis and have been suggested to participate in the immediate activation of adrenal steroidogenesis by adrenocorticotropic hormone (ACTH) [20].
  • Acute treatment with diazepam did not affect the dynamic state of brain DBI [21].

Regulatory relationships of Dbi


Other interactions of Dbi


Analytical, diagnostic and therapeutic context of Dbi

  • Brain TTN was purified by immunoaffinity chromatography with polyclonal octadecaneuropeptide, DBI 33-50) antibodies coupled to CNBr-Sepharose 4B followed by two reverse-phase HPLC steps [16].
  • To test the role of DBI in pancreatic secretion and responses to feeding, we used pancreaticobiliary and intestinal cannula to divert bile-pancreatic juice from anesthetized rats [11].
  • Using a perfusion system containing isolated mucosal cells from the proximal intestine of rats, porcine diazepam binding inhibitor 10(-12) M) dose dependently stimulated CCK secretion [12].
  • In the present study, we used a sandwich enzyme-linked immunosorbent assay to quantify ACBP concentration in different muscle fiber types [27].
  • Time-resolved fluorometry revealed that ACBP-bound parinaroyl-CoAs had high rotational freedom within the single, relatively hydrophobic (epsilon <32), binding site [28].


  1. Putative diazepam binding inhibitor peptide: cDNA clones from rat. Mocchetti, I., Einstein, R., Brosius, J. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  2. Pregnenolone biosynthesis in C6-2B glioma cell mitochondria: regulation by a mitochondrial diazepam binding inhibitor receptor. Papadopoulos, V., Guarneri, P., Kreuger, K.E., Guidotti, A., Costa, E. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  3. Potentiation of the antimitochondrial and antiproliferative effects of bis(guanylhydrazones) by phenethylbiguanide. Byczkowski, J.Z., Zychlinski, L., Porter, C.W. Cancer Res. (1982) [Pubmed]
  4. Physical and functional interaction of Acyl-CoA-binding protein with hepatocyte nuclear factor-4 alpha. Petrescu, A.D., Payne, H.R., Boedecker, A., Chao, H., Hertz, R., Bar-Tana, J., Schroeder, F., Kier, A.B. J. Biol. Chem. (2003) [Pubmed]
  5. Recombinant liver fatty acid binding protein interacts with fatty acyl-coenzyme A. Hubbell, T., Behnke, W.D., Woodford, J.K., Schroeder, F. Biochemistry (1994) [Pubmed]
  6. Psychological stress, but not physical stress, causes increase in diazepam binding inhibitor (DBI) mRNA expression in mouse brains. Katsura, M., Mohri, Y., Shuto, K., Tsujimura, A., Ukai, M., Ohkuma, S. Brain Res. Mol. Brain Res. (2002) [Pubmed]
  7. Beta-amyloid peptides stimulate endozepine biosynthesis in cultured rat astrocytes. Tokay, T., Masmoudi, O., Gandolfo, P., Leprince, J., Pelletier, G., Vaudry, H., Tonon, M.C. J. Neurochem. (2005) [Pubmed]
  8. Mitochondrial diazepam-binding inhibitor receptor complex agonists antagonize dizocilpine amnesia: putative role for allopregnanolone. Romeo, E., Cheney, D.L., Zivkovic, I., Costa, E., Guidotti, A. J. Pharmacol. Exp. Ther. (1994) [Pubmed]
  9. Conditioned place preference associates with the mRNA expression of diazepam binding inhibitor in brain regions of the addicted rat during withdrawal. Liu, X., Li, Y., Zhou, L., Chen, H., Su, Z., Hao, W. Brain Res. Mol. Brain Res. (2005) [Pubmed]
  10. Diazepam-binding inhibitor: a neuropeptide located in selected neuronal populations of rat brain. Alho, H., Costa, E., Ferrero, P., Fujimoto, M., Cosenza-Murphy, D., Guidotti, A. Science (1985) [Pubmed]
  11. Diazepam-binding inhibitor mediates feedback regulation of pancreatic secretion and postprandial release of cholecystokinin. Li, Y., Hao, Y., Owyang, C. J. Clin. Invest. (2000) [Pubmed]
  12. Diazepam binding inhibitor is a potent cholecystokinin-releasing peptide in the intestine. Herzig, K.H., Schön, I., Tatemoto, K., Ohe, Y., Li, Y., Fölsch, U.R., Owyang, C. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  13. Induction of hepatic acyl-CoA-binding protein and liver fatty acid-binding protein by perfluorodecanoic acid in rats. Lack of correlation with hepatic long-chain acyl-CoA levels. Sterchele, P.F., Vanden Heuvel, J.P., Davis, J.W., Shrago, E., Knudsen, J., Peterson, R.E. Biochem. Pharmacol. (1994) [Pubmed]
  14. Contrasting effects of E type prostaglandin (EP) receptor agonists on core body temperature in rats. Oka, T., Oka, K., Saper, C.B. Brain Res. (2003) [Pubmed]
  15. Cloning and tissue-specific functional characterization of the promoter of the rat diazepam binding inhibitor, a peptide with multiple biological actions. Kolmer, M., Alho, H., Costa, E., Pani, L. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  16. Isolation and characterization of a rat brain triakontatetraneuropeptide, a posttranslational product of diazepam binding inhibitor: specific action at the Ro 5-4864 recognition site. Slobodyansky, E., Guidotti, A., Wambebe, C., Berkovich, A., Costa, E. J. Neurochem. (1989) [Pubmed]
  17. Acyl-CoA-binding protein in the rat. Purification, binding characteristics, tissue concentrations and amino acid sequence. Knudsen, J., Højrup, P., Hansen, H.O., Hansen, H.F., Roepstorff, P. Biochem. J. (1989) [Pubmed]
  18. The gene encoding acyl-CoA-binding protein is subject to metabolic regulation by both sterol regulatory element-binding protein and peroxisome proliferator-activated receptor alpha in hepatocytes. Sandberg, M.B., Bloksgaard, M., Duran-Sandoval, D., Duval, C., Staels, B., Mandrup, S. J. Biol. Chem. (2005) [Pubmed]
  19. Regulation of pregnenolone synthesis in C6-2B glioma cells by 4'-chlorodiazepam. Guarneri, P., Papadopoulos, V., Pan, B., Costa, E. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  20. Diazepam-binding inhibitor (DBI)-processing products, acting at the mitochondrial DBI receptor, mediate adrenocorticotropic hormone-induced steroidogenesis in rat adrenal gland. Cavallaro, S., Korneyev, A., Guidotti, A., Costa, E. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  21. Protracted treatment with diazepam increases the turnover of putative endogenous ligands for the benzodiazepine/beta-carboline recognition site. Miyata, M., Mocchetti, I., Ferrarese, C., Guidotti, A., Costa, E. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  22. Somatostatin down-regulates the expression and release of endozepines from cultured rat astrocytes via distinct receptor subtypes. Masmoudi, O., Gandolfo, P., Tokay, T., Leprince, J., Ravni, A., Vaudry, H., Tonon, M.C. J. Neurochem. (2005) [Pubmed]
  23. Role of glucocorticoids in the modulation of corticotropin-releasing hormone mRNA level by the endogenous benzodiazepine receptor ligand octadecaneuropeptide in rat brain. Givalois, L., Li, S., Pelletier, G. Neuroendocrinology (1998) [Pubmed]
  24. Pituitary adenylate cyclase-activating polypeptide (PACAP) stimulates endozepine release from cultured rat astrocytes via a PKA-dependent mechanism. Masmoudi, O., Gandolfo, P., Leprince, J., Vaudry, D., Fournier, A., Patte-Mensah, C., Vaudry, H., Tonon, M.C. FASEB J. (2003) [Pubmed]
  25. Functional characterization and expression of PBR in rat gastric mucosa: stimulation of chloride secretion by PBR ligands. Ostuni, M.A., Marazova, K., Peranzi, G., Vidic, B., Papadopoulos, V., Ducroc, R., Lacapere, J.J. Am. J. Physiol. Gastrointest. Liver Physiol. (2004) [Pubmed]
  26. Acyl-CoA-binding protein is a potent m-calpain activator. Melloni, E., Averna, M., Salamino, F., Sparatore, B., Minafra, R., Pontremoli, S. J. Biol. Chem. (2000) [Pubmed]
  27. Acyl-CoA binding protein expression is fiber type- specific and elevated in muscles from the obese insulin-resistant Zucker rat. Franch, J., Knudsen, J., Ellis, B.A., Pedersen, P.K., Cooney, G.J., Jensen, J. Diabetes (2002) [Pubmed]
  28. Acyl coenzyme A binding protein. Conformational sensitivity to long chain fatty acyl-CoA. Frolov, A., Schroeder, F. J. Biol. Chem. (1998) [Pubmed]
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