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Gene Review

Dbi  -  diazepam binding inhibitor

Mus musculus

Synonyms: ACBD1, ACBP, Acbp, Acyl-CoA-binding protein, DBI, ...
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Disease relevance of Dbi

  • We show here that the relatively high basal promoter activity of the rat ACBP gene in fibroblasts and hepatoma cells relies on sequences between -331 to -182 and on the Sp1 and NF-Y sites at -172 and -143, respectively [1].
  • To test this hypothesis, mouse recombinant (mr) ACBP was engineered to contain the native mouse ACBP amino acid sequence expressed as a fusion protein at high levels (>150 mg/L) in Escherichia coli [2].
  • Here, we show that deletion of Acbp in mouse results in sebocyte hyperplasia and sparse, matted hair with a greasy appearance [3].

Psychiatry related information on Dbi

  • These data suggest a pivotal role for GABA-A and mitochondrial DBI receptors in the hyperphagic effects of neurosteroids and reinforces a role for endogenous neurosteroids in regulating feeding behavior [4].

High impact information on Dbi

  • Thus endozepine, a ligand of the peripheral benzodiazepin receptor (whose occupation may facilitate mitochondrial membrane permeabilization), was found among the released proteins [5].
  • Interestingly, the E prostanoid (EP) receptors EP2 and EP4 are elevated on donor-derived phagocytes post-BMT [6].
  • Pulmonary fibroblasts from untreated mice expressed all four E prostanoid (EP) receptors for PGE(2) [7].
  • By using PPARalpha expressed in Sf21 cells for electrophoretic mobility shift assays, we demonstrate that S-hexadecyl-CoA was able to increase the mobility of the PPARalpha-containing heterodimer even in the presence of a molar excess of acyl-CoA-binding protein, mimicking the conditions found in vivo [8].
  • Furthermore, in the clones with the highest levels of ACBP antisense expression, the induction of expression of the adipogenic transcription factors peroxisome proliferator-activated receptor gamma and CCAAT/enhancer-binding protein alpha as well as several adipocyte-specific genes was significantly delayed and reduced [9].

Chemical compound and disease context of Dbi


Biological context of Dbi


Anatomical context of Dbi

  • In addition, PPARalpha mediates the induction of ACBP expression in response to peroxisome proliferators [1].
  • In hepatocytes, SREBP-1c is the main regulator of ACBP in response to changes in insulin levels during fasting/refeeding [1].
  • Inhibition of 3T3-L1 adipocyte differentiation by expression of acyl-CoA-binding protein antisense RNA [9].
  • Pools of 3T3-L1 cells transfected with vectors expressing ACBP antisense RNA showed significantly less lipid accumulation as compared with cells transfected with the control vector [9].
  • Taken together, these data indicated for the first time that mrACBP interacted preferentially with anionic phospholipid-rich, highly curved membranes to facilitate transfer of ACBP-bound ligands [2].

Associations of Dbi with chemical compounds


Physical interactions of Dbi


Co-localisations of Dbi


Regulatory relationships of Dbi


Other interactions of Dbi

  • We present evidence that endogenous ACBP, ALBP, and KLBP not only localize to the cytoplasm but also exhibit a prominent nuclear localization in 3T3-L1 adipocytes [11].
  • In addition, forced expression of ACBP, ALBP, and KLBP in CV-1 cells resulted in a substantial accumulation of all three proteins in the nucleus [11].
  • (v) Cytoplasmic LCFA-CoA binding proteins such as acyl-CoA binding protein, sterol carrier protein-2, and liver-FA binding protein slowed the process of 16:1-CoA degradation proportional to their respective affinities for this ligand [18].
  • To resolve the role of fatty acyl CoA binding independent of cholesterol binding/transfer, a protein that exclusively binds fatty acyl CoA (acyl CoA binding protein, ACBP) was compared [16].
  • These EtOH-induced increases in DBI mRNA expression were further elevated after the additional cultivation of neurons under EtOH-free condition. beta-Actin mRNA expression was not altered by similar EtOH treatments [12].

Analytical, diagnostic and therapeutic context of Dbi


  1. ACBP--a PPAR and SREBP modulated housekeeping gene. Neess, D., Kiilerich, P., Sandberg, M.B., Helledie, T., Nielsen, R., Mandrup, S. Mol. Cell. Biochem. (2006) [Pubmed]
  2. Membrane charge and curvature determine interaction with acyl-CoA binding protein (ACBP) and fatty acyl-CoA targeting. Chao, H., Martin, G.G., Russell, W.K., Waghela, S.D., Russell, D.H., Schroeder, F., Kier, A.B. Biochemistry (2002) [Pubmed]
  3. Loss of the acyl-CoA binding protein (Acbp) results in fatty acid metabolism abnormalities in mouse hair and skin. Lee, L., DeBono, C.A., Campagna, D.R., Young, D.C., Moody, D.B., Fleming, M.D. J. Invest. Dermatol. (2007) [Pubmed]
  4. The role of GABA-A and mitochondrial diazepam-binding inhibitor receptors on the effects of neurosteroids on food intake in mice. Reddy, D.S., Kulkarni, S.K. Psychopharmacology (Berl.) (1998) [Pubmed]
  5. Mass spectrometric identification of proteins released from mitochondria undergoing permeability transition. Patterson, S.D., Spahr, C.S., Daugas, E., Susin, S.A., Irinopoulou, T., Koehler, C., Kroemer, G. Cell Death Differ. (2000) [Pubmed]
  6. Critical Role of Prostaglandin E2 Overproduction in Impaired Pulmonary Host Response following Bone Marrow Transplantation. Ballinger, M.N., Aronoff, D.M., McMillan, T.R., Cooke, K.R., Olkiewicz, K., Toews, G.B., Peters-Golden, M., Moore, B.B. J. Immunol. (2006) [Pubmed]
  7. Bleomycin-induced E prostanoid receptor changes alter fibroblast responses to prostaglandin E2. Moore, B.B., Ballinger, M.N., White, E.S., Green, M.E., Herrygers, A.B., Wilke, C.A., Toews, G.B., Peters-Golden, M. J. Immunol. (2005) [Pubmed]
  8. Acyl-CoA esters antagonize the effects of ligands on peroxisome proliferator-activated receptor alpha conformation, DNA binding, and interaction with Co-factors. Elholm, M., Dam, I., Jorgensen, C., Krogsdam, A.M., Holst, D., Kratchmarova, I., Gottlicher, M., Gustafsson, J.A., Berge, R., Flatmark, T., Knudsen, J., Mandrup, S., Kristiansen, K. J. Biol. Chem. (2001) [Pubmed]
  9. Inhibition of 3T3-L1 adipocyte differentiation by expression of acyl-CoA-binding protein antisense RNA. Mandrup, S., Sorensen, R.V., Helledie, T., Nohr, J., Baldursson, T., Gram, C., Knudsen, J., Kristiansen, K. J. Biol. Chem. (1998) [Pubmed]
  10. Sequence and expression of the murine diazepam binding inhibitor. Owens, G.P., Sinha, A.K., Sikela, J.M., Hahn, W.E. Brain Res. Mol. Brain Res. (1989) [Pubmed]
  11. Lipid-binding proteins modulate ligand-dependent trans-activation by peroxisome proliferator-activated receptors and localize to the nucleus as well as the cytoplasm. Helledie, T., Antonius, M., Sorensen, R.V., Hertzel, A.V., Bernlohr, D.A., Kølvraa, S., Kristiansen, K., Mandrup, S. J. Lipid Res. (2000) [Pubmed]
  12. Ethanol stimulates diazepam binding inhibitor (DBI) mRNA expression in primary cultured neurons. Katsura, M., Ohkuma, S., Jun, X., Tsujimura, A., Kuriyama, K. Brain Res. Mol. Brain Res. (1995) [Pubmed]
  13. Cellular localization of the diazepam binding inhibitor in glial cells with special reference to its coexistence with brain-type fatty acid binding protein. Yanase, H., Shimizu, H., Yamada, K., Iwanaga, T. Arch. Histol. Cytol. (2002) [Pubmed]
  14. Prostaglandin E receptor subtype EP(1) deficiency inhibits colon cancer development. Kawamori, T., Kitamura, T., Watanabe, K., Uchiya, N., Maruyama, T., Narumiya, S., Sugimura, T., Wakabayashi, K. Carcinogenesis (2005) [Pubmed]
  15. Diazepam binding inhibitor (DBI) reduces testosterone and estradiol levels in vivo. Dong, E., Matsumoto, K., Watanabe, H. Life Sci. (2002) [Pubmed]
  16. ACBP and cholesterol differentially alter fatty acyl CoA utilization by microsomal ACAT. Chao, H., Zhou, M., McIntosh, A., Schroeder, F., Kier, A.B. J. Lipid Res. (2003) [Pubmed]
  17. NMDA receptor activation enhances diazepam binding inhibitor and its mRNA expressions in mouse cerebral cortical neurons. Katsura, M., Takesue, M., Shuto, K., Mohri, Y., Tarumi, C., Tsujimura, A., Shirotani, K., Ohkuma, S. Brain Res. Mol. Brain Res. (2001) [Pubmed]
  18. Stability of fatty acyl-coenzyme A thioester ligands of hepatocyte nuclear factor-4alpha and peroxisome proliferator-activated receptor-alpha. Schroeder, F., Huang, H., Hostetler, H.A., Petrescu, A.D., Hertz, R., Bar-Tana, J., Kier, A.B. Lipids (2005) [Pubmed]
  19. Neurosteroid progesterone is up-regulated in the brain of jimpy and shiverer mice. Le Goascogne, C., Eychenne, B., Tonon, M.C., Lachapelle, F., Baumann, N., Robel, P. Glia (2000) [Pubmed]
  20. Nicotine increases diazepam binding inhibitor (DBI) mRNA in primary cultured neurons. Katsura, M., Ohkuma, S., Chen, D.T., Tsujimura, A., Kuriyama, K. Neurosci. Lett. (1994) [Pubmed]
  21. Diazepam binding inhibitor (DBI) gene expression in the brains of socially isolated and group-housed mice. Dong, E., Matsumoto, K., Tohda, M., Kaneko, Y., Watanabe, H. Neurosci. Res. (1999) [Pubmed]
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