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Gene Review

Dbi  -  Diazepam-binding inhibitor

Drosophila melanogaster

Synonyms: ACBP, Acyl-CoA-binding protein homolog, BcDNA:RH39533, CG8627, DBI, ...
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High impact information on Dbi

  • The cytochrome P450 Cyp6a2 and the diazepam-binding inhibitor gene (Dbi) were over transcribed in the two DDT-resistant genotypes when compared to the wild-type Drosophila, and this difference was significant at the most stringent statistical level, a Bonferroni correction [1].
  • The diazepam-binding inhibitor (DBI; also called acyl coenzyme A-binding protein or endozepine) is a 10-kDa polypeptide found in organisms ranging from yeasts to mammals [2].
  • In adult flies, DBI mRNA and immunoreactivity were detected in the cardia, part of the Malpighian tubules, the fat body, and gametes of both sexes [2].
  • It has been shown that DBI and its processing products are involved in various specific biological processes such as GABAA/benzodiazepine receptor modulation, acyl coenzyme A metabolism, steroidogenesis, and insulin secretion [2].
  • On the basis of the expression of DBI in some but not all tissues with high energy consumption, we propose that in D. melanogaster, DBI is involved in energy metabolism in a manner that depends on the substrate used for energy production [2].


  1. Genome-wide transcription profile of field- and laboratory-selected dichlorodiphenyltrichloroethane (DDT)-resistant Drosophila. Pedra, J.H., McIntyre, L.M., Scharf, M.E., Pittendrigh, B.R. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  2. Tissue-specific expression of the diazepam-binding inhibitor in Drosophila melanogaster: cloning, structure, and localization of the gene. Kolmer, M., Roos, C., Tirronen, M., Myöhänen, S., Alho, H. Mol. Cell. Biol. (1994) [Pubmed]
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