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Gene Review

XIAP  -  X-linked inhibitor of apoptosis

Gallus gallus

Synonyms: BIRC4, IAP3
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High impact information on BIRC4

  • Gene therapy delivering BIRC4 significantly promoted optic nerve axon survival in a chronic ocular hypertensive model of rat glaucoma [1].

Biological context of BIRC4

  • After chronic exposure to elevated intraocular pressure, we performed optic nerve axon counts to determine the neuroprotective effects of retinal BIRC4 expression, and compared axon survival with vector and balanced salt solution control groups [1].


  1. Baculoviral IAP repeat-containing-4 protects optic nerve axons in a rat glaucoma model. McKinnon, S.J., Lehman, D.M., Tahzib, N.G., Ransom, N.L., Reitsamer, H.A., Liston, P., LaCasse, E., Li, Q., Korneluk, R.G., Hauswirth, W.W. Mol. Ther. (2002) [Pubmed]
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