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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

SSTR2  -  somatostatin receptor 2

Gallus gallus

 
 
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High impact information on SSTR2

  • The expression of SSTR2 mRNA by the thyrotropes was low during embryonic development and increased just before hatching [1].
  • A SSTR2 selective agonist (L-779,976) potently inhibited both basal and GH-releasing hormone (GHRH)-stimulated GH release at low nanomolar concentrations [2].
  • Reverse transcription-polymerase chain reaction (RT-PCR) and Northern blot analysis using a partial cDNA for chicken SSTR2 showed relatively high levels of SSTR2 mRNA in the anterior pituitary (both in the caudal and cephalic lobes) and brain and detectable levels in liver, muscle, heart and small intestine [2].

References

  1. Increasing plasma thyroxine levels during late embryogenesis and hatching in the chicken are not caused by an increased sensitivity of the thyrotropes to hypothalamic stimulation. De Groef, B., Grommen, S.V., Darras, V.M. J. Endocrinol. (2006) [Pubmed]
  2. Identification of the somatostatin receptor subtypes involved in regulation of growth hormone secretion in chickens. Bossis, I., Porter, T.E. Mol. Cell. Endocrinol. (2001) [Pubmed]
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