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Gene Review

SSTR2  -  somatostatin receptor 2

Gallus gallus

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High impact information on SSTR2

  • The expression of SSTR2 mRNA by the thyrotropes was low during embryonic development and increased just before hatching [1].
  • A SSTR2 selective agonist (L-779,976) potently inhibited both basal and GH-releasing hormone (GHRH)-stimulated GH release at low nanomolar concentrations [2].
  • Reverse transcription-polymerase chain reaction (RT-PCR) and Northern blot analysis using a partial cDNA for chicken SSTR2 showed relatively high levels of SSTR2 mRNA in the anterior pituitary (both in the caudal and cephalic lobes) and brain and detectable levels in liver, muscle, heart and small intestine [2].


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