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Gene Review

Sstr2  -  somatostatin receptor 2

Mus musculus

Synonyms: SRIF-1, SS-2-R, SS2-R, SS2R, SSTR-2, ...
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Disease relevance of Sstr2


Psychiatry related information on Sstr2

  • In behavioural tests, Sstr2-null mice showed normal levels of locomotor activity and normal coordination in undemanding tasks [5].
  • Spatial discrimination learning in the radial maze was facilitated in sst2 KO mice, while operant learning of a bar-pressing task was slightly altered [6].

High impact information on Sstr2


Chemical compound and disease context of Sstr2


Biological context of Sstr2

  • In an investigation of the molecular mechanisms controlling these patterns, we have recently shown that binding of the transcription factor SEF-2 to a novel initiator element in the SSTR-2 promoter is essential for SSTR-2 gene expression [13].
  • SSTR2A and SSTR2B are generated by alternative splicing of SSTR2 mRNA [14].
  • These findings differ from the results of similar mutagenesis studies on other G protein-linked receptors, in that the mutant and wild-type SSTR2 forms associate with G proteins in similar ways [15].
  • SRIF-1 binding site radioautography indicated that 10% of hypothalamic neurons were labelled on both cell bodies and neuritic processes, as were 35% of astrocytes [16].
  • We conclude that sst2 compensates for SRIF absence and that its upregulation is responsible for reduced bursting and decreased excitatory transmission in KO mice [17].

Anatomical context of Sstr2


Associations of Sstr2 with chemical compounds


Physical interactions of Sstr2

  • Several regions of the brain reported to contain dense somatostatin-like immunoreactive terminal fields and receptor binding sites were devoid of both SSTR1 and SSTR2 mRNA, suggesting the existence of additional SSTR subtypes [19].

Regulatory relationships of Sstr2


Other interactions of Sstr2


Analytical, diagnostic and therapeutic context of Sstr2

  • By comparison to previously published in situ hybridization and immunohistochemical data, Sstr2lacZ expression was shown to accurately recapitulate that of Sstr2 and thus provided a highly sensitive model to investigate cell-type-specific expression of Sstr2 [5].
  • Somatostatin receptor subtypes sst1 and sst2 elicit opposite effects on the response to glutamate of mouse hypothalamic neurones: an electrophysiological and single cell RT-PCR study [2].
  • Amplification of mRNA by reverse transcription PCR shows SSTR1, SSTR2, and SSTR3 mRNA in normal mouse brain and other tissues [26].
  • In Chinese hamster ovary (CHO) cells stably expressing the mouse SSTR2 gene (CHOB), the antibody 2e3 recognized specifically a protein of 93-kDa protein by immunoblotting [27].
  • This suggests that SSTR1 is involved in modulating basal GH levels in primary pituitary cell cultures and, together with SSTR2, may control the secretion of GH in the body [28].


  1. Thyroid hormone-responsive pituitary hyperplasia independent of somatostatin receptor 2. Brinkmeier, M.L., Stahl, J.H., Gordon, D.F., Ross, B.D., Sarapura, V.D., Dowding, J.M., Kendall, S.K., Lloyd, R.V., Ridgway, E.C., Camper, S.A. Mol. Endocrinol. (2001) [Pubmed]
  2. Somatostatin receptor subtypes sst1 and sst2 elicit opposite effects on the response to glutamate of mouse hypothalamic neurones: an electrophysiological and single cell RT-PCR study. Lanneau, C., Viollet, C., Faivre-Bauman, A., Loudes, C., Kordon, C., Epelbaum, J., Gardette, R. Eur. J. Neurosci. (1998) [Pubmed]
  3. Involvement of sst2 somatostatin receptor in locomotor, exploratory activity and emotional reactivity in mice. Viollet, C., Vaillend, C., Videau, C., Bluet-Pajot, M.T., Ungerer, A., L'Héritier, A., Kopp, C., Potier, B., Billard, J., Schaeffer, J., Smith, R.G., Rohrer, S.P., Wilkinson, H., Zheng, H., Epelbaum, J. Eur. J. Neurosci. (2000) [Pubmed]
  4. Somatostatin receptors in wildtype and somatostatin deficient mice and their involvement in nitric oxide physiology in the retina. Mastrodimou, N., Vasilaki, A., Papadioti, A., Low, M.J., Hoyer, D., Thermos, K. Neuropeptides (2006) [Pubmed]
  5. Somatostatin receptor 2 knockout/lacZ knockin mice show impaired motor coordination and reveal sites of somatostatin action within the striatum. Allen, J.P., Hathway, G.J., Clarke, N.J., Jowett, M.I., Topps, S., Kendrick, K.M., Humphrey, P.P., Wilkinson, L.S., Emson, P.C. Eur. J. Neurosci. (2003) [Pubmed]
  6. Spatial learning and synaptic hippocampal plasticity in type 2 somatostatin receptor knock-out mice. Dutar, P., Vaillend, C., Viollet, C., Billard, J.M., Potier, B., Carlo, A.S., Ungerer, A., Epelbaum, J. Neuroscience (2002) [Pubmed]
  7. Induction of a negative autocrine loop by expression of sst2 somatostatin receptor in NIH 3T3 cells. Rauly, I., Saint-Laurent, N., Delesque, N., Buscail, L., Estéve, J.P., Vaysse, N., Susini, C. J. Clin. Invest. (1996) [Pubmed]
  8. High basal gastric acid secretion in somatostatin receptor subtype 2 knockout mice. Martinez, V., Curi, A.P., Torkian, B., Schaeffer, J.M., Wilkinson, H.A., Walsh, J.H., Taché, Y. Gastroenterology (1998) [Pubmed]
  9. Somatostatin coupling to adenylyl cyclase activity in the mouse retina. Pavan, B., Fiorini, S., Dal Monte, M., Lunghi, L., Biondi, C., Bagnoli, P., Cervia, D. Naunyn Schmiedebergs Arch. Pharmacol. (2004) [Pubmed]
  10. Somatostatin-induced inhibition of neurotransmission in the mouse isolated vas deferens is resistant to pertussis toxin. Feniuk, W., Humphrey, P.P. Eur. J. Pharmacol. (1994) [Pubmed]
  11. Antitumor effect of in vivo somatostatin receptor subtype 2 gene transfer in primary and metastatic pancreatic cancer models. Vernejoul, F., Faure, P., Benali, N., Calise, D., Tiraby, G., Pradayrol, L., Susini, C., Buscail, L. Cancer Res. (2002) [Pubmed]
  12. Gi alpha 1 selectively couples somatostatin receptors to adenylyl cyclase in pituitary-derived AtT-20 cells. Tallent, M., Reisine, T. Mol. Pharmacol. (1992) [Pubmed]
  13. Activation of somatostatin receptor II expression by transcription factors MIBP1 and SEF-2 in the murine brain. Dörflinger, U., Pscherer, A., Moser, M., Rümmele, P., Schüle, R., Buettner, R. Mol. Cell. Biol. (1999) [Pubmed]
  14. Splice variant of the somatostatin receptor 2 subtype, somatostatin receptor 2B, couples to adenylyl cyclase. Reisine, T., Kong, H., Raynor, K., Yano, H., Takeda, J., Yasuda, K., Bell, G.I. Mol. Pharmacol. (1993) [Pubmed]
  15. Mutation of an aspartate at residue 89 in somatostatin receptor subtype 2 prevents Na+ regulation of agonist binding but does not alter receptor-G protein association. Kong, H., Raynor, K., Yasuda, K., Bell, G.I., Reisine, T. Mol. Pharmacol. (1993) [Pubmed]
  16. Distinct patterns of expression and physiological effects of sst1 and sst2 receptor subtypes in mouse hypothalamic neurons and astrocytes in culture. Viollet, C., Lanneau, C., Faivre-Bauman, A., Zhang, J., Djordjijevic, D., Loudes, C., Gardette, R., Kordon, C., Epelbaum, J. J. Neurochem. (1997) [Pubmed]
  17. Compensatory changes in the hippocampus of somatostatin knockout mice: upregulation of somatostatin receptor 2 and its function in the control of bursting activity and synaptic transmission. Cammalleri, M., Cervia, D., Dal Monte, M., Martini, D., Langenegger, D., Fehlmann, D., Feuerbach, D., Pavan, B., Hoyer, D., Bagnoli, P. Eur. J. Neurosci. (2006) [Pubmed]
  18. Identification of cells expressing somatostatin receptor 2 in the gastrointestinal tract of Sstr2 knockout/lacZ knockin mice. Allen, J.P., Canty, A.J., Schulz, S., Humphrey, P.P., Emson, P.C., Young, H.M. J. Comp. Neurol. (2002) [Pubmed]
  19. Differential expression of somatostatin receptor subtypes in brain. Breder, C.D., Yamada, Y., Yasuda, K., Seino, S., Saper, C.B., Bell, G.I. J. Neurosci. (1992) [Pubmed]
  20. Somatostatin modulation of excitatory synaptic transmission between periventricular and arcuate hypothalamic nuclei in vitro. Lanneau, C., Peineau, S., Petit, F., Epelbaum, J., Gardette, R. J. Neurophysiol. (2000) [Pubmed]
  21. Somatostatin inhibits insulin and glucagon secretion via two receptors subtypes: an in vitro study of pancreatic islets from somatostatin receptor 2 knockout mice. Strowski, M.Z., Parmar, R.M., Blake, A.D., Schaeffer, J.M. Endocrinology (2000) [Pubmed]
  22. Somatostatin stimulates ductal bile absorption and inhibits ductal bile secretion in mice via SSTR2 on cholangiocytes. Gong, A.Y., Tietz, P.S., Muff, M.A., Splinter, P.L., Huebert, R.C., Strowski, M.Z., Chen, X.M., LaRusso, N.F. Am. J. Physiol., Cell Physiol. (2003) [Pubmed]
  23. Differential regulation of somatostatin receptor type 2 (sst 2) expression in AR4-2J tumor cells implanted into mice during octreotide treatment. Froidevaux, S., Hintermann, E., Török, M., Mäcke, H.R., Beglinger, C., Eberle, A.N. Cancer Res. (1999) [Pubmed]
  24. Synthesis and biological activities of potent peptidomimetics selective for somatostatin receptor subtype 2. Yang, L., Berk, S.C., Rohrer, S.P., Mosley, R.T., Guo, L., Underwood, D.J., Arison, B.H., Birzin, E.T., Hayes, E.C., Mitra, S.W., Parmar, R.M., Cheng, K., Wu, T.J., Butler, B.S., Foor, F., Pasternak, A., Pan, Y., Silva, M., Freidinger, R.M., Smith, R.G., Chapman, K., Schaeffer, J.M., Patchett, A.A. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  25. Somatostatin receptor type 5 modulates somatostatin receptor type 2 regulation of adrenocorticotropin secretion. Ben-Shlomo, A., Wawrowsky, K.A., Proekt, I., Wolkenfeld, N.M., Ren, S.G., Taylor, J., Culler, M.D., Melmed, S. J. Biol. Chem. (2005) [Pubmed]
  26. T lymphocytes isolated from the hepatic granulomas of schistosome-infected mice express somatostatin receptor subtype II (SSTR2) messenger RNA. Elliott, D.E., Metwali, A., Blum, A.M., Sandor, M., Lynch, R., Weinstock, J.V. J. Immunol. (1994) [Pubmed]
  27. Immunological detection of isoforms of the somatostatin receptor subtype, SSTR2. Theveniau, M.A., Yasuda, K., Bell, G.I., Reisine, T. J. Neurochem. (1994) [Pubmed]
  28. Somatostatin receptor subtype 1 modulates basal inhibition of growth hormone release in somatotrophs. Kreienkamp, H.J., Akgün, E., Baumeister, H., Meyerhof, W., Richter, D. FEBS Lett. (1999) [Pubmed]
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