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Gene Review:

ECE1 - endothelin converting enzyme 1

Gallus gallus

Hall, C.E. et al., Takebayashi-Suzuki, K. et al., Cruz, A. et al.

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High impact information on ECE1

Thus, localized expression of ECE1 defines the site of Purkinje fiber recruitment in embryonic myocardium [1].
In the embryonic chick heart, ET receptors are expressed by all myocytes, but ECE1 is predominantly expressed in endothelial cells of coronary arteries and endocardium along which Purkinje fiber recruitment from myocytes takes place [1].
Furthermore, co-expression of exogenous ECE1 and ET-precursor in the embryonic heart is sufficient to ectopically convert cardiomyocytes into Purkinje fibers [1].
ET converting enzyme-1 (ECE-1), however, is expressed preferentially in endothelial cells of the endocardium and coronary arteries where Purkinje fiber recruitment takes place [2].
These results suggest that expression of ECE-1 plays a key role in defining an active site of ET signaling in the heart, thereby determining the timing and location of Purkinje fiber differentiation within the embryonic myocardium [2].

Associations of ECE1 with chemical compounds

The specific involvement of ET-1 in the angiogenic effect mediated by CHO-ET-1 was demonstrated by the reduction or abolition of neovascularized CHO-ET-1 nodules by (1) bosentan, a mixed antagonist of ET(A)/ET(B) receptors, (2) an ET(A) receptor antagonist (Ru69986) and (3) phosporamidon, an inhibitor of endothelin-converting enzyme-1 (ECE-1) [3].

References

Hemodynamic-dependent patterning of endothelin converting enzyme 1 expression and differentiation of impulse-conducting Purkinje fibers in the embryonic heart. Hall, C.E., Hurtado, R., Hewett, K.W., Shulimovich, M., Poma, C.P., Reckova, M., Justus, C., Pennisi, D.J., Tobita, K., Sedmera, D., Gourdie, R.G., Mikawa, T. Development (2004) [Pubmed]
In vivo induction of cardiac Purkinje fiber differentiation by coexpression of preproendothelin-1 and endothelin converting enzyme-1. Takebayashi-Suzuki, K., Yanagisawa, M., Gourdie, R.G., Kanzawa, N., Mikawa, T. Development (2000) [Pubmed]
Endothelin-1, a regulator of angiogenesis in the chick chorioallantoic membrane. Cruz, A., Parnot, C., Ribatti, D., Corvol, P., Gasc, J.M. J. Vasc. Res. (2001) [Pubmed]

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AgaP_AGAP007796	Anopheles gambiae str. PEST
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ece1	Danio rerio
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