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Gene Review

ECE1  -  endothelin converting enzyme 1

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High impact information on ECE1


Associations of ECE1 with chemical compounds

  • The specific involvement of ET-1 in the angiogenic effect mediated by CHO-ET-1 was demonstrated by the reduction or abolition of neovascularized CHO-ET-1 nodules by (1) bosentan, a mixed antagonist of ET(A)/ET(B) receptors, (2) an ET(A) receptor antagonist (Ru69986) and (3) phosporamidon, an inhibitor of endothelin-converting enzyme-1 (ECE-1) [3].


  1. Hemodynamic-dependent patterning of endothelin converting enzyme 1 expression and differentiation of impulse-conducting Purkinje fibers in the embryonic heart. Hall, C.E., Hurtado, R., Hewett, K.W., Shulimovich, M., Poma, C.P., Reckova, M., Justus, C., Pennisi, D.J., Tobita, K., Sedmera, D., Gourdie, R.G., Mikawa, T. Development (2004) [Pubmed]
  2. In vivo induction of cardiac Purkinje fiber differentiation by coexpression of preproendothelin-1 and endothelin converting enzyme-1. Takebayashi-Suzuki, K., Yanagisawa, M., Gourdie, R.G., Kanzawa, N., Mikawa, T. Development (2000) [Pubmed]
  3. Endothelin-1, a regulator of angiogenesis in the chick chorioallantoic membrane. Cruz, A., Parnot, C., Ribatti, D., Corvol, P., Gasc, J.M. J. Vasc. Res. (2001) [Pubmed]
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