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Gene Review

FRZB  -  frizzled-related protein

Gallus gallus

 
 
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High impact information on FRZB

  • In this study, we demonstrate spatially restricted expression of both Wnt-9a (formerly Wnt-14) and the secreted Wnt antagonist Frzb in AV endocardial cushions of the developing chicken heart [1].
  • Together, these data argue that Wnt-9a and Frzb regulate mesenchymal cell proliferation leading to proper AV canal cushion outgrowth and remodeling in the developing avian heart [1].
  • Here, we offer an in depth in situ gene expression study of Wnt ligands, frizzled receptors, and frizzled related modulators over several days of chicken gut development [2].

References

  1. Frzb modulates Wnt-9a-mediated beta-catenin signaling during avian atrioventricular cardiac cushion development. Person, A.D., Garriock, R.J., Krieg, P.A., Runyan, R.B., Klewer, S.E. Dev. Biol. (2005) [Pubmed]
  2. Wnt signaling components in the chicken intestinal tract. McBride, H.J., Fatke, B., Fraser, S.E. Dev. Biol. (2003) [Pubmed]
 
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