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Gene Review

FZD1  -  frizzled family receptor 1

Gallus gallus

Synonyms: Fz-1, cFz-1
 
 
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High impact information on FZD1

  • In somite explants, Fz1, beta-catenin and Lef1 are expressed prior to activation of myogenesis in response to Shh and Wnt signals [1].
  • Misexpression of putative dominant-negative forms of the two Frizzled proteins results in severe shortening of the infected cartilage elements due to a delay in chondrocyte maturation, indicating that an endogenous Wnt signal does indeed function to promote chondrogenic differentiation [2].
  • Here, we offer an in depth in situ gene expression study of Wnt ligands, frizzled receptors, and frizzled related modulators over several days of chicken gut development [3].
  • In situ hybridization revealed that genes for three Frizzled receptors, c-Fz1, c-Fz7, and c-Fz10, are expressed in and adjacent to sensory primordia, while Wnt4 is expressed in adjacent, nonsensory regions of the cochlear duct [4].
  • We used these data to generate a schematic composite of expression patterns at the level of the segmental plate and developing somites (stage V) that shows multiple Frizzled and Wnt transcripts expressed in tissues that are overlapping and adjacent to Myf-5 and MyoD expressing tissues [5].
 

Biological context of FZD1

  • In all, frizzled genes show dynamic expression at key times during embryonic development, particularly in the cranial placodes [6].
  • To isolate genes expressed in the head organizer, we screened a prechordal plate cDNA library by sequencing and expression pattern, and isolated the Xenopus ortholog of chick crescent encoding a Frizzled-like domain that is related to Wnt-binding regions of the Frizzled-family proteins [7].
  • Two broiler stocks were studied; each was segregated for four genotypes with regard to the genes for naked neck (Na) and frizzled feathers (F): heterozygous naked neck (Na/na f/f), heterozygous frizzle (na/na F/f), double heterozygous (Na/na F/f), and normally feathered (na/na f/f) [8].
 

Anatomical context of FZD1

  • Expression of Wnt and Frizzled genes during chick limb bud development [9].
  • To examine the role(s) of Wnt members and their transmembrane-spanning receptor(s), Frizzled (fz), we retrovirally misexpressed Wnt-5a, Wnt-7a, chicken frizzled-1 (Chfz-1), and frizzled-7 (Chfz-7) in long-term (21 day) high density, micromass cultures of stage 23/24 chick embryonic limb mesenchyme [10].
  • Xenopus crescent encoding a Frizzled-like domain is expressed in the Spemann organizer and pronephros [7].
  • Haemolytic complement activity and humoral immune responses to sheep red blood cells in indigenous chickens and in eight German Dahlem Red chicken lines with different combinations of major genes (dwarf, naked neck and frizzled) of tropical interest [11].
 

Associations of FZD1 with chemical compounds

  • Secreted frizzled related proteins (Sfrps) are thought to bind and regulate Wnt activity through a cysteine rich domain that is highly similar to that of Frizzled receptors [12].
 

Other interactions of FZD1

  • Chick frizzled-1 (cFz-1) is expressed in the lens, otic placode and, along with cFz-7, in epibranchial placodes [6].
  • Thus, we sought to determine which Wnts and Frizzled exhibit expression patterns that are spatiotemporally consistent with the expression of two myogenic determination factors: Myf-5 and MyoD [5].
  • Crescent encodes a protein that in its N-terminal half shows the characteristic invariant 9 cysteine residues of the cysteine-rich domain (CRD) found in the Frizzled family of proteins, in Smoothened and in Collagen XVIII [13].

References

  1. Expression of (beta)-catenin in the developing chick myotome is regulated by myogenic signals. Schmidt, M., Tanaka, M., Münsterberg, A. Development (2000) [Pubmed]
  2. Dual roles of Wnt signaling during chondrogenesis in the chicken limb. Hartmann, C., Tabin, C.J. Development (2000) [Pubmed]
  3. Wnt signaling components in the chicken intestinal tract. McBride, H.J., Fatke, B., Fraser, S.E. Dev. Biol. (2003) [Pubmed]
  4. Forced activation of Wnt signaling alters morphogenesis and sensory organ identity in the chicken inner ear. Stevens, C.B., Davies, A.L., Battista, S., Lewis, J.H., Fekete, D.M. Dev. Biol. (2003) [Pubmed]
  5. Comparative analysis of the expression patterns of Wnts and Frizzleds during early myogenesis in chick embryos. Cauthen, C.A., Berdougo, E., Sandler, J., Burrus, L.W. Mech. Dev. (2001) [Pubmed]
  6. Characterization of avian frizzled genes in cranial placode development. Stark, M.R., Biggs, J.J., Schoenwolf, G.C., Rao, M.S. Mech. Dev. (2000) [Pubmed]
  7. Xenopus crescent encoding a Frizzled-like domain is expressed in the Spemann organizer and pronephros. Shibata, M., Ono, H., Hikasa, H., Shinga, J., Taira, M. Mech. Dev. (2000) [Pubmed]
  8. The effects of the naked neck (Na) and frizzle (F) genes on growth and meat yield of broilers and their interactions with ambient temperatures and potential growth rate. Yunis, R., Cahaner, A. Poult. Sci. (1999) [Pubmed]
  9. Expression of Wnt and Frizzled genes during chick limb bud development. Kengaku, M., Twombly, V., Tabin, C. Cold Spring Harb. Symp. Quant. Biol. (1997) [Pubmed]
  10. Long-term in vitro analysis of limb cartilage development: involvement of Wnt signaling. Daumer, K.M., Tufan, A.C., Tuan, R.S. J. Cell. Biochem. (2004) [Pubmed]
  11. Haemolytic complement activity and humoral immune responses to sheep red blood cells in indigenous chickens and in eight German Dahlem Red chicken lines with different combinations of major genes (dwarf, naked neck and frizzled) of tropical interest. Baelmans, R., Parmentier, H.K., Nieuwland, M.G., Dorny, P., Demey, F., Berkvens, D. Tropical animal health and production. (2005) [Pubmed]
  12. Sfrp-1 and sfrp-2 are expressed in overlapping and distinct domains during chick development. Terry, K., Magan, H., Baranski, M., Burrus, L.W. Mech. Dev. (2000) [Pubmed]
  13. Crescent, a novel chick gene encoding a Frizzled-like cysteine-rich domain, is expressed in anterior regions during early embryogenesis. Pfeffer, P.L., De Robertis, E.M., Izpisua-Belmonte, J.C. Int. J. Dev. Biol. (1997) [Pubmed]
 
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