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Gene Review

WNT9A  -  wingless-type MMTV integration site family...

Gallus gallus

Synonyms: WNT-14, WNT14
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High impact information on WNT9A

  • In this study, we demonstrate spatially restricted expression of both Wnt-9a (formerly Wnt-14) and the secreted Wnt antagonist Frzb in AV endocardial cushions of the developing chicken heart [1].
  • Weak expression of Wnt 14 is observed at the proximal mesenchyme of the limb at HH stage 23; later, it extends as a transverse strip surrounding the cartilage elements as well as in the interdigital mesenchyme [2].
  • Interzone cells isolated and reared in vitro expressed typical phenotypic markers, including GDF-5, Wnt-14, and CD-44, and differentiated into chondrocytes over time [3].


  1. Frzb modulates Wnt-9a-mediated beta-catenin signaling during avian atrioventricular cardiac cushion development. Person, A.D., Garriock, R.J., Krieg, P.A., Runyan, R.B., Klewer, S.E. Dev. Biol. (2005) [Pubmed]
  2. Comparative analysis of the expression patterns of Wnts during chick limb development. Loganathan, P.G., Nimmagadda, S., Huang, R., Scaal, M., Christ, B. Histochem. Cell Biol. (2005) [Pubmed]
  3. Cellular and molecular mechanisms of synovial joint and articular cartilage formation. Pacifici, M., Koyama, E., Shibukawa, Y., Wu, C., Tamamura, Y., Enomoto-Iwamoto, M., Iwamoto, M. Ann. N. Y. Acad. Sci. (2006) [Pubmed]
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