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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

SPON1  -  spondin 1, extracellular matrix protein

Gallus gallus

 
 
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High impact information on SPON1

  • Injection of purified F-spondin protein into the lumen of the spinal cord of chicken embryos in ovo resulted in longitudinal turning of commissural axons before reaching the floor plate, whereas neutralizing antibody (Ab) injections caused lateral turning at the contralateral floor plate boundary [1].
  • F-spondin, a protein produced and secreted by the floor plate, promotes adhesion and neurite extension of commissural neurons in vitro [1].
  • F-Spondin, expressed in somite regions avoided by neural crest cells, mediates inhibition of distinct somite domains to neural crest migration [2].
  • Conversely, F-spondin antibodies prevented rounding up of NC cells on CS [2].

References

  1. F-Spondin is required for accurate pathfinding of commissural axons at the floor plate. Burstyn-Cohen, T., Tzarfaty, V., Frumkin, A., Feinstein, Y., Stoeckli, E., Klar, A. Neuron (1999) [Pubmed]
  2. F-Spondin, expressed in somite regions avoided by neural crest cells, mediates inhibition of distinct somite domains to neural crest migration. Debby-Brafman, A., Burstyn-Cohen, T., Klar, A., Kalcheim, C. Neuron (1999) [Pubmed]
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