Disease relevance of SPON1

• VSGP/F-spondin: a new ovarian cancer marker [1].

High impact information on SPON1

• Plasmin-mediated release of the guidance molecule F-spondin from the extracellular matrix [2].
• The malaria circumsporozoite protein (CS), thrombospondin (TSP), and several other proteins including the terminal complement proteins and the neural adhesion molecules F-spondin and Unc-5, share a cell adhesive sequence [3].
• To investigate the evolution of chordate F-spondin genes, I have used the basal position in chordate phylogeny of the acraniate amphioxus [4].
• Vascular smooth muscle cell growth-promoting factor (VSGP) was originally isolated from bovine ovarian follicular fluid as a stimulator of vascular smooth muscle cell proliferation [5].
• Here, we examined whether recombinant human VSGP/F-spondin affected the biological activities of endothelial cells [5].

Biological context of SPON1

• Nucleotide sequence analysis revealed that bovine VSGP transcript has a 2421-bp open reading frame, which encodes a protein of 807 amino acid residues [6].
• Taken together, these results suggest that rHuEpo may function as a vascular smooth muscle cell growth promoting factor through activation of the phospholipase C cascade and a modulation of proto-oncogene expression [7].
• Interestingly, F-spondin highly expressing HPL cells showed similar phenotype of cementoblasts, such as up-regulation of mineralized-related genes [8].

Anatomical context of SPON1

• A protein possessing vascular smooth muscle cell (SMC) growth-promoting activity (VSGP) was purified from bovine ovarian follicular fluid [6].
• Effect of F-spondin on cementoblastic differentiation of human periodontal ligament cells [8].
• During the development of the sympathetic nervous system, the migration of trunk neural crest cells through the somites is influenced by ephrin-Bs, Sema3A and F-spondin [9].
• In all cases the spontaneous and pokeweed mitogen-induced in vitro production of Ig by peripheral blood lymphocytes was evaluated at the beginning of the study and the ratio stimulated/spontaneous (Stim/Spon) synthesis was calculated [10].

Associations of SPON1 with chemical compounds

• These results indicate that VSGP/F-spondin inhibits angiogenesis at least in part by the blockade of endothelial integrin alphavbeta3 [5].

Other interactions of SPON1

• Their analysis by a combined mass spectrometric approach is illustrated with peptides from the thrombospondin type 1 repeats (TSRs) of the recombinant axonal guidance protein F-spondin [11].
• F-spondin and Mindin are evolutionarily conserved proteins [12].
• This review samples some of the contemporary literature regarding TSR superfamily members (e.g. F-spondin, UNC-5, ADAMTS, papilin, and TRAP) where specific functions are assigned to the TSR domains [13].
• These include the F-spondin gene family, the members of the semaphorin 5 family, UNC-5, SCO-spondin, and others [14].

References