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Gene Review:

pceA - tetrachloroethene dehalogenase

Desulfitobacterium hafniense Y51

Suyama, A. et al., Futagami, T. et al., Maillard, J. et al.

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Disease relevance of pceA

The pceA gene of Desulfitobacterium sp. strain Y51 was identified in a 2.8-kb DNA fragment and used to express the protein in Escherichia coli for the preparation of antibodies [1].

High impact information on pceA

The dehalorespiring Desulfitobacterium hafniense strain Y51 efficiently dechlorinates tetrachloroethene (PCE) to cis-1,2-dichloroethene (cis-DCE) via trichloroethene by PceA reductive dehalogenase encoded by the pceA gene [2].
Whereas the cprB (chlorophenol reductive dehalogenase) genes of chlorophenol-dehalorespiring bacteria are always located upstream of cprA, all pceB genes known so far are located downstream of pceA [3].
The tetrachloroethene (PCE) reductive dehalogenase (encoded by the pceA gene and designated PceA dehalogenase) of Desulfitobacterium sp. strain Y51 was purified and characterized [1].

References

Molecular characterization of the PceA reductive dehalogenase of desulfitobacterium sp. strain Y51. Suyama, A., Yamashita, M., Yoshino, S., Furukawa, K. J. Bacteriol. (2002) [Pubmed]
Effects of Chloromethanes on Growth of and Deletion of the pce Gene Cluster in Dehalorespiring Desulfitobacterium hafniense Strain Y51. Futagami, T., Yamaguchi, T., Nakayama, S., Goto, M., Furukawa, K. Appl. Environ. Microbiol. (2006) [Pubmed]
Characterization of the corrinoid iron-sulfur protein tetrachloroethene reductive dehalogenase of Dehalobacter restrictus. Maillard, J., Schumacher, W., Vazquez, F., Regeard, C., Hagen, W.R., Holliger, C. Appl. Environ. Microbiol. (2003) [Pubmed]

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