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Chemical Compound Review

Perchlorethylene     1,1,2,2-tetrachloroethene

Synonyms: Didakene, Perchlor, Perclene, Perklone, Tetracap, ...
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Disease relevance of Tetrachlorethylene


Psychiatry related information on Tetrachlorethylene

  • Observations on the performance of the same animals in an open-field situation revealed that ambulation was affected in experiments with tetrachlorethylene immediately after exposure while preening pattern was changed after exposure to dichlormethane [6].
  • IP administration of 1.0 g/kg body weight of tetrachloroethylene at 0900 h produced a remarkable phase-shift (4.0 +/- 0.9 h) in the activity rhythm and an increase in the slope of fluctuation (0.4 +/- 0.1) in contrast to a relatively smaller decrease in the total amount of spontaneous locomotor activity [7].
  • We evaluated colour vision in 35 dry-cleaners exposed to perchloroethylene (PCE) and in a paired number of controls matched for sex, age, alcohol consumption and cigarette smoking [8].
  • A decision making process was implemented in Vermont when it became necessary to have an interim ambient air exposure level to test for tetrachloroethylene contamination in the water, air, and soil of a community [9].

High impact information on Tetrachlorethylene


Chemical compound and disease context of Tetrachlorethylene


Biological context of Tetrachlorethylene


Anatomical context of Tetrachlorethylene


Associations of Tetrachlorethylene with other chemical compounds

  • The order of potency for inhibition (IC50) was PERC (270 microM) > TOL (720 microM) > TCE (1525 microM) [27].
  • Anoxic biodegradation was of prime importance for halomineralization of pulp bleaching organohalogens but could also lead to toxic metabolites such as vinyl chloride from tri- and tetrachloroethene in anoxic soil [28].
  • While many anaerobic microbial communities are capable of reductively dechlorinating tetrachloroethene (PCE) and trichloroethene (TCE) to dichloroethene (DCE), vinyl chloride (VC), and finally ethene, the accumulation of the highly toxic intermediates, cis-DCE (cDCE) and VC, presents a challenge for bioremediation processes [29].
  • We analysed the frequency data from workers grouped by internal systemic burdens of plutonium (less than 148, 148-740 and greater than 740 Bq) and to those exposed to five chemicals in the workplace: perchloroethylene, beryllium, carbon tetrachloride, benzene, and trichloroethylene [30].
  • Bioactivation of tetrachloroethylene. Role of glutathione S-transferase-catalyzed conjugation versus cytochrome P-450-dependent phospholipid alkylation [31].

Gene context of Tetrachlorethylene


Analytical, diagnostic and therapeutic context of Tetrachlorethylene


  1. Hepatic and renal toxicities associated with perchloroethylene. Lash, L.H., Parker, J.C. Pharmacol. Rev. (2001) [Pubmed]
  2. Aerobic degradation of tetrachloroethylene by toluene-o-xylene monooxygenase of Pseudomonas stutzeri OX1. Ryoo, D., Shim, H., Canada, K., Barbieri, P., Wood, T.K. Nat. Biotechnol. (2000) [Pubmed]
  3. The familial occurrence of polycythemia vera: report of a father and son, with consideration of the possible etiologic role of exposure to organic solvents, including tetrachloroethylene. Ratnoff, W.D., Gress, R.E. Blood (1980) [Pubmed]
  4. Isolation and characterization of Tn-Dha1, a transposon containing the tetrachloroethene reductive dehalogenase of Desulfitobacterium hafniense strain TCE1. Maillard, J., Regeard, C., Holliger, C. Environ. Microbiol. (2005) [Pubmed]
  5. Tetrachloroethylene-contaminated drinking water and the risk of breast cancer. Aschengrau, A., Paulu, C., Ozonoff, D. Environ. Health Perspect. (1998) [Pubmed]
  6. Biochemical and behavioural effects of inhalation exposure to tetrachlorethylene and dichlormethane. Savolainen, H., Pfäffli, P., Tengén, M., Vainio, H. J. Neuropathol. Exp. Neurol. (1977) [Pubmed]
  7. Assessment of behavioral effects of tetrachloroethylene using a set of time-series analyses. Motohashi, Y., Miyazaki, Y., Takano, T. Neurotoxicology and teratology. (1993) [Pubmed]
  8. Perchloroethylene exposure can induce colour vision loss. Cavalleri, A., Gobba, F., Paltrinieri, M., Fantuzzi, G., Righi, E., Aggazzotti, G. Neurosci. Lett. (1994) [Pubmed]
  9. Establishment of an exposure level to tetrachloroethylene in ambient air in Vermont. Coffin, R.R., Witherell, L.E., Novick, L.F., Stone, K.M. Public health reports (Washington, D.C. : 1974) (1987) [Pubmed]
  10. Nephropathies and exposure to perchloroethylene in dry-cleaners. Mutti, A., Alinovi, R., Bergamaschi, E., Biagini, C., Cavazzini, S., Franchini, I., Lauwerys, R.R., Bernard, A.M., Roels, H., Gelpi, E. Lancet (1992) [Pubmed]
  11. Theoretical investigations into the intermediacy of chlorinated vinylcobalamins in the reductive dehalogenation of chlorinated ethylenes. Pratt, D.A., van der Donk, W.A. J. Am. Chem. Soc. (2005) [Pubmed]
  12. ras proto-oncogene activation in dichloroacetic acid-, trichloroethylene- and tetrachloroethylene-induced liver tumors in B6C3F1 mice. Anna, C.H., Maronpot, R.R., Pereira, M.A., Foley, J.F., Malarkey, D.E., Anderson, M.W. Carcinogenesis (1994) [Pubmed]
  13. 16S rRNA gene-based detection of tetrachloroethene-dechlorinating Desulfuromonas and Dehalococcoides species. Löffler, F.E., Sun, Q., Li, J., Tiedje, J.M. Appl. Environ. Microbiol. (2000) [Pubmed]
  14. Potentiating effects of chlorinated hydrocarbons on carbon tetrachloride toxicity in isolated rat hepatocytes and plasma membranes. Kefalas, V., Stacey, N.H. Toxicol. Appl. Pharmacol. (1991) [Pubmed]
  15. N-acetyl-S-(1,2,2-trichlorovinyl)-L-cysteine and 2,2,2-trichloroethanol: two novel metabolites of tetrachloroethene in humans after occupational exposure. Birner, G., Rutkowska, A., Dekant, W. Drug Metab. Dispos. (1996) [Pubmed]
  16. Emergence of two types of nondechlorinating variants in the tetrachloroethene-halorespiring Desulfitobacterium sp. strain Y51. Futagami, T., Tsuboi, Y., Suyama, A., Goto, M., Furukawa, K. Appl. Microbiol. Biotechnol. (2006) [Pubmed]
  17. Epinephrine-induced cardiac arrhythmias in rabbits exposed to tetrachloroethylene. Carlson, G.P. Toxicol. Lett. (1983) [Pubmed]
  18. In silico toxicology: simulating interaction thresholds for human exposure to mixtures of trichloroethylene, tetrachloroethylene, and 1,1,1-trichloroethane. Dobrev, I.D., Andersen, M.E., Yang, R.S. Environ. Health Perspect. (2002) [Pubmed]
  19. Redox chemistry of cobalamin and iron-sulfur cofactors in the tetrachloroethene reductase of Dehalobacter restrictus. Schumacher, W., Holliger, C., Zehnder, A.J., Hagen, W.R. FEBS Lett. (1997) [Pubmed]
  20. Biotransformation of tetrachloroethylene to trichloroethylene, dichloroethylene, vinyl chloride, and carbon dioxide under methanogenic conditions. Vogel, T.M., McCarty, P.L. Appl. Environ. Microbiol. (1985) [Pubmed]
  21. Update of residential tetrachloroethylene exposure and decreases in visual contrast sensitivity. Storm, J.E., Mazor, K.A. Environ. Health Perspect. (2004) [Pubmed]
  22. Tetrachloroethene dehalogenase from Dehalospirillum multivorans: cloning, sequencing of the encoding genes, and expression of the pceA gene in Escherichia coli. Neumann, A., Wohlfarth, G., Diekert, G. J. Bacteriol. (1998) [Pubmed]
  23. Tetrachloroethylene-contaminated drinking water in Massachusetts and the risk of colon-rectum, lung, and other cancers. Paulu, C., Aschengrau, A., Ozonoff, D. Environ. Health Perspect. (1999) [Pubmed]
  24. Computer simulation of the lactational transfer of tetrachloroethylene in rats using a physiologically based model. Byczkowski, J.Z., Kinkead, E.R., Leahy, H.F., Randall, G.M., Fisher, J.W. Toxicol. Appl. Pharmacol. (1994) [Pubmed]
  25. Quantitation of N epsilon-(dichloroacetyl)-L-lysine in proteins after perchloroethene exposure by gas chromatography-mass spectrometry using chemical ionization and negative ion detection followingimmunoaffinity chromatography. Pähler, A., Völkel, W., Dekant, W. Journal of chromatography. A. (1999) [Pubmed]
  26. The role of trichloracetic acid and peroxisome proliferation in the differences in carcinogenicity of perchloroethylene in the mouse and rat. Odum, J., Green, T., Foster, J.R., Hext, P.M. Toxicol. Appl. Pharmacol. (1988) [Pubmed]
  27. Perturbation of voltage-sensitive Ca2+ channel function by volatile organic solvents. Shafer, T.J., Bushnell, P.J., Benignus, V.A., Woodward, J.J. J. Pharmacol. Exp. Ther. (2005) [Pubmed]
  28. Organic halogens in the environment: studies of environmental biodegradability and human exposure. Salkinoja-Salonen, M., Uotila, J., Jokela, J., Laine, M., Saski, E. Environ. Health Perspect. (1995) [Pubmed]
  29. Discrimination of multiple dehalococcoides strains in a trichloroethene enrichment by quantification of their reductive dehalogenase genes. Holmes, V.F., He, J., Lee, P.K., Alvarez-Cohen, L. Appl. Environ. Microbiol. (2006) [Pubmed]
  30. Sister chromatid exchanges and chromosome aberration frequencies in plutonium workers. Brandom, W.F., McGavran, L., Bistline, R.W., Bloom, A.D. Int. J. Radiat. Biol. (1990) [Pubmed]
  31. Bioactivation of tetrachloroethylene. Role of glutathione S-transferase-catalyzed conjugation versus cytochrome P-450-dependent phospholipid alkylation. Dekant, W., Martens, G., Vamvakas, S., Metzler, M., Henschler, D. Drug Metab. Dispos. (1987) [Pubmed]
  32. The role of CYP forms in the metabolism and metabolic activation of HCFCs and other halocarbons. White, I.N., De Matteis, F. Toxicol. Lett. (2001) [Pubmed]
  33. Molecular characterization of the PceA reductive dehalogenase of desulfitobacterium sp. strain Y51. Suyama, A., Yamashita, M., Yoshino, S., Furukawa, K. J. Bacteriol. (2002) [Pubmed]
  34. gamma-Glutamyltransferase isoenzyme pattern in workers exposed to tetrachloroethylene. Gennari, P., Naldi, M., Motta, R., Nucci, M.C., Giacomini, C., Violante, F.S., Raffi, G.B. Am. J. Ind. Med. (1992) [Pubmed]
  35. The influence of maternal exposure to volatile organic compounds on the cytokine secretion profile of neonatal T cells. Lehmann, I., Thoelke, A., Rehwagen, M., Rolle-Kampczyk, U., Schlink, U., Schulz, R., Borte, M., Diez, U., Herbarth, O. Environ. Toxicol. (2002) [Pubmed]
  36. Tetrachloroethylene (PCE, Perc) levels in residential dry cleaner buildings in diverse communities in New York City. McDermott, M.J., Mazor, K.A., Shost, S.J., Narang, R.S., Aldous, K.M., Storm, J.E. Environ. Health Perspect. (2005) [Pubmed]
  37. Metabolism of tetrachloroethene in rats: identification of N epsilon-(dichloroacetyl)-L-lysine and N epsilon-(trichloroacetyl)-L-lysine as protein adducts. Birner, G., Richling, C., Henschler, D., Anders, M.W., Dekant, W. Chem. Res. Toxicol. (1994) [Pubmed]
  38. Apartment residents' and day care workers' exposures to tetrachloroethylene and deficits in visual contrast sensitivity. Schreiber, J.S., Hudnell, H.K., Geller, A.M., House, D.E., Aldous, K.M., Force, M.S., Langguth, K., Prohonic, E.J., Parker, J.C. Environ. Health Perspect. (2002) [Pubmed]
  39. Coexistence of a sulphate-reducing Desulfovibrio species and the dehalorespiring Desulfitobacterium frappieri TCE1 in defined chemostat cultures grown with various combinations of sulfate and tetrachloroethene. Drzyzga, O., Gerritse, J., Dijk, J.A., Elissen, H., Gottschal, J.C. Environ. Microbiol. (2001) [Pubmed]
  40. Transcription and mass-spectroscopic proteomic studies of electron transport oxidoreductases in Dehalococcoides ethenogenes. Morris, R.M., Sowell, S., Barofsky, D., Zinder, S., Richardson, R. Environ. Microbiol. (2006) [Pubmed]
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