Disease relevance of Tetrachlorethylene

• Hepatic and renal toxicities associated with perchloroethylene [1].
• Aerobic degradation of tetrachloroethylene by toluene-o-xylene monooxygenase of Pseudomonas stutzeri OX1 [2].
• The occurrence of polycythemia vera in a father and son, both of whom had intermittent exposure to organic solvents, including tetrachloroethylene and Stoddard solvent, is reported [3].
• Isolation and characterization of Tn-Dha1, a transposon containing the tetrachloroethene reductive dehalogenase of Desulfitobacterium hafniense strain TCE1 [4].
• Tetrachloroethylene-contaminated drinking water and the risk of breast cancer [5].

Psychiatry related information on Tetrachlorethylene

• Observations on the performance of the same animals in an open-field situation revealed that ambulation was affected in experiments with tetrachlorethylene immediately after exposure while preening pattern was changed after exposure to dichlormethane [6].
• IP administration of 1.0 g/kg body weight of tetrachloroethylene at 0900 h produced a remarkable phase-shift (4.0 +/- 0.9 h) in the activity rhythm and an increase in the slope of fluctuation (0.4 +/- 0.1) in contrast to a relatively smaller decrease in the total amount of spontaneous locomotor activity [7].
• We evaluated colour vision in 35 dry-cleaners exposed to perchloroethylene (PCE) and in a paired number of controls matched for sex, age, alcohol consumption and cigarette smoking [8].
• A decision making process was implemented in Vermont when it became necessary to have an interim ambient air exposure level to test for tetrachloroethylene contamination in the water, air, and soil of a community [9].

High impact information on Tetrachlorethylene

• Thus, in a collaborative European study, we assessed the renal effects of occupational exposure to perchloroethylene (PCE) in dry-cleaners compared with matched controls who were simultaneously examined [10].
• The reductive dehalogenation of perchloroethylene and trichloroethylene by vitamin B(12) produces approximately 95% (Z)-dichloroethylene (DCE) and small amounts of (E)-DCE and 1,1-DCE, which are further reduced to ethylene and ethane [11].
• Biochemical and behavioural effects of inhalation exposure to tetrachlorethylene and dichlormethane [6].
• There was also a higher incidence of K-ras activation (13%) in tetrachloroethylene-induced tumors than in the other chemically induced or control tumors [12].
• The H-ras codon 61 mutation frequency for tetrachloroethylene-induced tumors was significantly lower (24%) than that of combined controls and also that of the two other chemicals [12].

Chemical compound and disease context of Tetrachlorethylene

• Members of the genera Desulfuromonas and Dehalococcoides reductively dechlorinate tetrachloroethene (PCE) and trichloroethene [13].
• Hepatocyte suspensions were exposed to carbon tetrachloride at subthreshold levels of toxicity and various concentrations of 1,1,1-trichloroethane, tetrachloroethylene, and chloroform over an eightfold concentration range [14].
• The glutathione conjugation pathway has been implicated in the chronic toxicity and possible tumorigenicity of tetrachloroethene to the kidney in rats [15].
• Desulfitobacterium sp. strain Y51 exhibits a strong dechlorinating activity for tetrachloroethene (PCE), converting it to cis-1,2-dichloroethene via trichloroethene by the action of the PceA reductive dehalogenase (encoded by pceA) [16].
• Epinephrine-induced cardiac arrhythmias in rabbits exposed to tetrachloroethylene [17].

Biological context of Tetrachlorethylene

• Thus, we developed an interactive physiologically based pharmacokinetic (PBPK) model to predict the individual kinetics of trichloroethylene (TCE), perchloroethylene (PERC), and methylchloroform (MC) in humans exposed to differently constituted chemical mixtures of the three solvents [18].
• The terminal component of the respiratory chain is the membrane-bound tetrachloroethene reductase [19].
• Biotransformation of tetrachloroethylene to trichloroethylene, dichloroethylene, vinyl chloride, and carbon dioxide under methanogenic conditions [20].
• Update of residential tetrachloroethylene exposure and decreases in visual contrast sensitivity [21].
• Four peptides obtained after trypsin treatment of tetrachloroethene (PCE) dehalogenase were found in the deduced amino acid sequence of pceA [22].

Anatomical context of Tetrachlorethylene

• We conducted a population-based case-control study to evaluate the relationship between cancer of the colon-rectum (n = 326), lung (n = 252), brain (n = 37), and pancreas (n = 37), and exposure to tetrachloroethylene (PCE) from public drinking water [23].
• In liver plasma membranes no changes in Na(+)-K(+)-ATPase were observed with any of the treatments and only the highest dose of tetrachloroethylene was able to inhibit Mg(2+)-ATPase activity [14].
• A physiologically based pharmacokinetic (PBPK) model describing transfer of inhaled tetrachloroethylene (PCE) into breast milk with the consequent exposure of the nursing pups was developed and validated in lactating rats [24].
• Dichloroacetylated proteins from rat kidney mitochondria, rat plasma and human blood plasma were isolated after exposure to 40 ppm tetrachloroethene (PER) for 6 h [25].
• The role of trichloracetic acid and peroxisome proliferation in the differences in carcinogenicity of perchloroethylene in the mouse and rat [26].

Associations of Tetrachlorethylene with other chemical compounds

• The order of potency for inhibition (IC50) was PERC (270 microM) > TOL (720 microM) > TCE (1525 microM) [27].
• Anoxic biodegradation was of prime importance for halomineralization of pulp bleaching organohalogens but could also lead to toxic metabolites such as vinyl chloride from tri- and tetrachloroethene in anoxic soil [28].
• While many anaerobic microbial communities are capable of reductively dechlorinating tetrachloroethene (PCE) and trichloroethene (TCE) to dichloroethene (DCE), vinyl chloride (VC), and finally ethene, the accumulation of the highly toxic intermediates, cis-DCE (cDCE) and VC, presents a challenge for bioremediation processes [29].
• We analysed the frequency data from workers grouped by internal systemic burdens of plutonium (less than 148, 148-740 and greater than 740 Bq) and to those exposed to five chemicals in the workplace: perchloroethylene, beryllium, carbon tetrachloride, benzene, and trichloroethylene [30].
• Bioactivation of tetrachloroethylene. Role of glutathione S-transferase-catalyzed conjugation versus cytochrome P-450-dependent phospholipid alkylation [31].

Gene context of Tetrachlorethylene

• For perchloroethylene, the extent of activation is less and the reaction is catalysed primarily by the CYP2B family [32].
• The tetrachloroethene (PCE) reductive dehalogenase (encoded by the pceA gene and designated PceA dehalogenase) of Desulfitobacterium sp. strain Y51 was purified and characterized [33].
• gamma-Glutamyltransferase isoenzyme pattern in workers exposed to tetrachloroethylene [34].
• Exposure to tetrachloroethylene was associated with reduced percentages of interferon-gamma-producing (IFN-gamma) type 1 T cells (OR = 2.9) [35].
• Fugitive tetrachloroethylene (PCE, perc) emissions from dry cleaners operating in apartment buildings can contaminate residential indoor air [36].

Analytical, diagnostic and therapeutic context of Tetrachlorethylene

• We conducted a population-based case-control study to evaluate the relationship between cases of breast cancer and exposure to tetrachloroethylene (PCE) from public drinking water ( n = 258 cases and 686 controls) [5].
• In this report, we demonstrate the formation of protein adducts formed from tetrachloroethene using SDS-PAGE and immunochemical detection with rabbit anti-trifluoroacetyl serum [37].
• Apartment residents' and day care workers' exposures to tetrachloroethylene and deficits in visual contrast sensitivity [38].
• A two-member co-culture consisting of the dehalorespiring Desulfitobacterium frappieri TCE1 and the sulphate-reducing Desulfovibrio sp. strain SULF1 was obtained via anaerobic enrichment from soil contaminated with tetrachloroethene (PCE) [39].
• Using quantitative reverse transcriptase polymerase chain reaction, we found that genes encoding a periplasmic Hup hydrogenase and the Fdh were the most highly expressed in batch-grown pure cultures, in which the H2 partial pressure was >0.1 atm, and in butyrate/tetrachloroethene-mixed cultures, in which H2 partial pressures were 10(-4)-10(-5) atm [40].

References