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Chemical Compound Review

AG-C-96478     1,2-dichloroethene

Synonyms: ACMC-209tcb, ACMC-20alfp, ANW-42297, CTK0H5190, CTK1G9758, ...
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Disease relevance of trans-Acetylene dichloride


High impact information on trans-Acetylene dichloride


Biological context of trans-Acetylene dichloride

  • The cis and trans isomers of 1,2-dichloroethylene were tested for mutagenic effects in a diploid strain (D7) of the yeast Saccharomyces cerevisiae in suspension tests with and without a mammalian microsomal activation system, an S9 mouse liver fraction, and by an in vivo intrasanguineous host mediated assay [9].

Anatomical context of trans-Acetylene dichloride


Associations of trans-Acetylene dichloride with other chemical compounds


Analytical, diagnostic and therapeutic context of trans-Acetylene dichloride

  • A competitive PCR (cPCR) assay targeting 16S ribosomal DNA was developed to enumerate growth of a Dehalococcoides-like microorganism, bacterium VS, from a mixed culture catalyzing the reductive dehalogenation of cis-1,2-dichloroethene (cDCE) and vinyl chloride (VC), with hydrogen being used as an electron donor [13].
  • In both batch and bioreactor configurations, Tenax not only maintained low, steady-state concentrations of PCE in an active culture for several months but also adsorbed the product of dechlorination, cis-1,2-dichloroethene, before it approached toxic levels [14].
  • Quantitation of 1,1- and 1,2-dichloroethylene in body tissues by purge-and-trap gas chromatography [15].


  1. Cation-recognized photosensitization in E-Z isomerization of 1,2-dichloroethylene by crowned benzophenones. Kokubo, K., Kakimoto, H., Oshima, T. J. Am. Chem. Soc. (2002) [Pubmed]
  2. Effects of Chloromethanes on Growth of and Deletion of the pce Gene Cluster in Dehalorespiring Desulfitobacterium hafniense Strain Y51. Futagami, T., Yamaguchi, T., Nakayama, S., Goto, M., Furukawa, K. Appl. Environ. Microbiol. (2006) [Pubmed]
  3. Toxicity of 1,1-dichloroethane and 1,2-dichloroethylene determined using cultured human KB cells. Mochida, K., Gomyoda, M., Fujita, T. Bulletin of environmental contamination and toxicology. (1995) [Pubmed]
  4. Ru-Catalyzed asymmetric hydrogenation of alpha-ketoesters with CeCl3.7H2O as additive. Sun, Y., Wan, X., Wang, J., Meng, Q., Zhang, H., Jiang, L., Zhang, Z. Org. Lett. (2005) [Pubmed]
  5. Characterization of the corrinoid iron-sulfur protein tetrachloroethene reductive dehalogenase of Dehalobacter restrictus. Maillard, J., Schumacher, W., Vazquez, F., Regeard, C., Hagen, W.R., Holliger, C. Appl. Environ. Microbiol. (2003) [Pubmed]
  6. A modeling study and implications of competition between Dehalococcoides ethenogenes and other tetrachloroethene-respiring bacteria. Becker, J.G. Environ. Sci. Technol. (2006) [Pubmed]
  7. Assessment of indigenous reductive dechlorinating potential at a TCE-contaminated site using microcosms, polymerase chain reaction analysis, and site data. Fennell, D.E., Carroll, A.B., Gossett, J.M., Zinder, S.H. Environ. Sci. Technol. (2001) [Pubmed]
  8. Tetrachloroethene metabolism of Dehalospirillum multivorans. Neumann, A., Scholz-Muramatsu, H., Diekert, G. Arch. Microbiol. (1994) [Pubmed]
  9. Comparative genetic activity of cis- and trans-1,2-dichloroethylene in yeast. Bronzetti, G., Bauer, C., Corsi, C., Del Carratore, R., Galli, A., Nieri, R., Paolini, M., Cundari, E., Cantelli Forti, G., Crenshaw, J. Teratog., Carcinog. Mutagen. (1984) [Pubmed]
  10. An investigation into the activation and deactivation of chlorinated hydrocarbons to genotoxins in metabolically competent human cells. Doherty, A.T., Ellard, S., Parry, E.M., Parry, J.M. Mutagenesis (1996) [Pubmed]
  11. Purification and characterization of the tetrachloroethene reductive dehalogenase of strain PCE-S. Miller, E., Wohlfarth, G., Diekert, G. Arch. Microbiol. (1998) [Pubmed]
  12. Temperature dependence of anaerobic TCE-dechlorination in a highly enriched Dehalococcoides-containing culture. Friis, A.K., Heimann, A.C., Jakobsen, R., Albrechtsen, H.J., Cox, E., Bjerg, P.L. Water Res. (2007) [Pubmed]
  13. Growth of a Dehalococcoides-like microorganism on vinyl chloride and cis-dichloroethene as electron acceptors as determined by competitive PCR. Cupples, A.M., Spormann, A.M., McCarty, P.L. Appl. Environ. Microbiol. (2003) [Pubmed]
  14. Continuous steady-state method using tenax for delivering tetrachloroethene to chloro-respiring bacteria. Brennan, R.A., Sanford, R.A. Appl. Environ. Microbiol. (2002) [Pubmed]
  15. Quantitation of 1,1- and 1,2-dichloroethylene in body tissues by purge-and-trap gas chromatography. Lin, S.N., Fu, F.W., Bruckner, J.V. J. Chromatogr. (1982) [Pubmed]
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