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Gene Review

WNT9A  -  wingless-type MMTV integration site family...

Homo sapiens

Synonyms: Protein Wnt-14, Protein Wnt-9a, WNT14
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Disease relevance of WNT9A


High impact information on WNT9A

  • From the screen, we selected three bidirectional gene pairs for detailed analysis, WNT9A/CD558500, CTDSPL/BC040563, and KCNK15/BF195580 [2].
  • We also deduced the full-length amino acid sequence of its close relative, Wnt9a (also called Wnt14), from unannotated genomic DNA sequences in GenBank [4].
  • We have isolated a number of WNT sequences from human genomic DNA, two of which, designated WNT14 and WNT15, represent novel members of the Wnt gene family [5].
  • The 3.0-kb WNT3A mRNA was moderately expressed in placenta, and the 4.4-kb WNT14 mRNA was moderately expressed in skeletal muscle and heart [6].
  • Among 3 human breast cancer cell lines, WNT14 mRNA was expressed in T-47D cells, and weakly expressed in MCF-7 cells [3].

Biological context of WNT9A


Anatomical context of WNT9A

  • Mouse Wnt14 mRNA was expressed in adult brain, lung, skeletal muscle, heart, and 17-day embryo [7].
  • Interzone cells isolated and reared in vitro expressed typical phenotypic markers, including GDF-5, Wnt-14, and CD-44, and differentiated into chondrocytes over time [8].

Associations of WNT9A with chemical compounds

  • These results indicate that WNT14 is a target gene of IFNgamma in MKN45 cells, and that WNT14B is a target gene of estrogen in MCF-7 cells [3].

Analytical, diagnostic and therapeutic context of WNT9A


  1. Comparative genomics on Wnt9a orthologs. Katoh, Y., Katoh, M. Oncol. Rep. (2005) [Pubmed]
  2. Silencing of bidirectional promoters by DNA methylation in tumorigenesis. Shu, J., Jelinek, J., Chang, H., Shen, L., Qin, T., Chung, W., Oki, Y., Issa, J.P. Cancer Res. (2006) [Pubmed]
  3. Expression of WNT14 and WNT14B mRNAs in human cancer, up-regulation of WNT14 by IFNgamma and up-regulation of WNT14B by beta-estradiol. Kirikoshi, H., Sekihara, H., Katoh, M. Int. J. Oncol. (2001) [Pubmed]
  4. Mouse Wnt9b transforming activity, tissue-specific expression, and evolution. Qian, J., Jiang, Z., Li, M., Heaphy, P., Liu, Y.H., Shackleford, G.M. Genomics (2003) [Pubmed]
  5. Isolation of two novel WNT genes, WNT14 and WNT15, one of which (WNT15) is closely linked to WNT3 on human chromosome 17q21. Bergstein, I., Eisenberg, L.M., Bhalerao, J., Jenkins, N.A., Copeland, N.G., Osborne, M.P., Bowcock, A.M., Brown, A.M. Genomics (1997) [Pubmed]
  6. Molecular cloning and characterization of WNT3A and WNT14 clustered in human chromosome 1q42 region. Saitoh, T., Hirai, M., Katoh, M. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  7. Molecular cloning and expression of mouse Wnt14, and structural comparison between mouse Wnt14-Wnt3a gene cluster and human WNT14-WNT3A gene cluster. Katoh, M. Int. J. Mol. Med. (2002) [Pubmed]
  8. Cellular and molecular mechanisms of synovial joint and articular cartilage formation. Pacifici, M., Koyama, E., Shibukawa, Y., Wu, C., Tamamura, Y., Enomoto-Iwamoto, M., Iwamoto, M. Ann. N. Y. Acad. Sci. (2006) [Pubmed]
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