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Gene Review

Wnt9a  -  wingless-type MMTV integration site family...

Mus musculus

Synonyms: Protein Wnt-14, Protein Wnt-9a, Wnt14
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Disease relevance of Wnt9a

  • We show that loss of Wnt9a does not affect joint induction, but results to synovial chondroid metaplasia in some joints [1].

High impact information on Wnt9a


Biological context of Wnt9a


Anatomical context of Wnt9a

  • Ectopic expression of an activated form of beta-catenin or Wnt14 in early differentiating chondrocytes induced ectopic joint formation both morphologically and molecularly [2].

Associations of Wnt9a with chemical compounds

  • Rat Wnt9a protein (365 aa) with N-terminal signal peptide, 24 Cys residues and one Asn-linked glycosylation site showed 100%, 98.1% and 82.5% total amino-acid identity with mouse Wnt9a, human WNT9A and chicken wnt9a, respectively [5].


  1. Wnt9a signaling is required for joint integrity and regulation of Ihh during chondrogenesis. Später, D., Hill, T.P., O'sullivan, R.J., Gruber, M., Conner, D.A., Hartmann, C. Development (2006) [Pubmed]
  2. Wnt/beta-catenin signaling is sufficient and necessary for synovial joint formation. Guo, X., Day, T.F., Jiang, X., Garrett-Beal, L., Topol, L., Yang, Y. Genes Dev. (2004) [Pubmed]
  3. Mouse Wnt9b transforming activity, tissue-specific expression, and evolution. Qian, J., Jiang, Z., Li, M., Heaphy, P., Liu, Y.H., Shackleford, G.M. Genomics (2003) [Pubmed]
  4. Cellular and molecular mechanisms of synovial joint and articular cartilage formation. Pacifici, M., Koyama, E., Shibukawa, Y., Wu, C., Tamamura, Y., Enomoto-Iwamoto, M., Iwamoto, M. Ann. N. Y. Acad. Sci. (2006) [Pubmed]
  5. Comparative genomics on Wnt9a orthologs. Katoh, Y., Katoh, M. Oncol. Rep. (2005) [Pubmed]
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