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Gene Review:

Wnt9a - wingless-type MMTV integration site family...

Mus musculus

Synonyms: Protein Wnt-14, Protein Wnt-9a, Wnt14

Katoh, Y. et al., Später, D. et al., Guo, X. et al., Qian, J. et al., Pacifici, M. et al.

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Disease relevance of Wnt9a

We show that loss of Wnt9a does not affect joint induction, but results to synovial chondroid metaplasia in some joints [1].

High impact information on Wnt9a

Removal of beta-catenin early in mesenchymal progenitor cells promoted chondrocyte differentiation and blocked the activity of Wnt14 in joint formation [2].
Loss of Wnt9a activity results in transient downregulation of Ihh and reduced Ihh-signaling activity at E12.5-E13 [1].
Full-length comparisons among Wnt amino acid sequences provide evidence that Wnt9b and Wnt9a are close paralogs of each other and are orthologs of Wnt9 genes from shark and hagfish [3].
Interzone cells isolated and reared in vitro expressed typical phenotypic markers, including GDF-5, Wnt-14, and CD-44, and differentiated into chondrocytes over time [4].
Comparative genomics on Wnt9a orthologs [5].

Biological context of Wnt9a

Wnt9a signaling is required for joint integrity and regulation of Ihh during chondrogenesis [1].
Here we identified and characterized rat Wnt9a gene by using bioinformatics [5].
Rat Wnt9a gene, consisting of four exons, was located within AC121055.4 and AC133374.2 genome sequences [5].
In addition, Wnt9a gene is implicated in chondrogenesis and joint formation during embryogenesis [5].
Transcription-factor-binding sites conserved between human WNT9A and rodent Wnt9a 5'-flanking promoter regions were not identified by using the Match program [5].

Anatomical context of Wnt9a

Ectopic expression of an activated form of beta-catenin or Wnt14 in early differentiating chondrocytes induced ectopic joint formation both morphologically and molecularly [2].

Associations of Wnt9a with chemical compounds

Rat Wnt9a protein (365 aa) with N-terminal signal peptide, 24 Cys residues and one Asn-linked glycosylation site showed 100%, 98.1% and 82.5% total amino-acid identity with mouse Wnt9a, human WNT9A and chicken wnt9a, respectively [5].

References

Wnt9a signaling is required for joint integrity and regulation of Ihh during chondrogenesis. Später, D., Hill, T.P., O'sullivan, R.J., Gruber, M., Conner, D.A., Hartmann, C. Development (2006) [Pubmed]
Wnt/beta-catenin signaling is sufficient and necessary for synovial joint formation. Guo, X., Day, T.F., Jiang, X., Garrett-Beal, L., Topol, L., Yang, Y. Genes Dev. (2004) [Pubmed]
Mouse Wnt9b transforming activity, tissue-specific expression, and evolution. Qian, J., Jiang, Z., Li, M., Heaphy, P., Liu, Y.H., Shackleford, G.M. Genomics (2003) [Pubmed]
Cellular and molecular mechanisms of synovial joint and articular cartilage formation. Pacifici, M., Koyama, E., Shibukawa, Y., Wu, C., Tamamura, Y., Enomoto-Iwamoto, M., Iwamoto, M. Ann. N. Y. Acad. Sci. (2006) [Pubmed]
Comparative genomics on Wnt9a orthologs. Katoh, Y., Katoh, M. Oncol. Rep. (2005) [Pubmed]

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