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Gene Review:

DIO3 - deiodinase, iodothyronine, type III

Gallus gallus

Van der Geyten, S. et al., Verhoelst, C.H. et al., Darras, V.M. et al.

Verhoelst, Vandenborne, Severi, Bakker, Zandieh Doulabi, Leonard, Kühn, van der Geyten, Darras,

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High impact information on DIO3

Specific detection of type III iodothyronine deiodinase protein in chicken cerebellar purkinje cells [1].
In brain, the presence of type III iodothyronine deiodinase (D3) seems to be important to maintain homeostasis of T(3) levels [1].
Growth hormone acutely decreases type III iodothyronine deiodinase in chicken liver [2].
Acute pretranslational regulation of type III iodothyronine deiodinase by growth hormone and dexamethasone in chicken embryos [3].
Studies on chicken embryos demonstrated that intravenous (i.v.) injection of chicken GH or glucocorticoids results in increased plasma 3,3',5-triiodothyronine (T3) concentrations, and this through a reduction of hepatic type III iodothyronine deiodinase (D3) activity [3].

References

Specific detection of type III iodothyronine deiodinase protein in chicken cerebellar purkinje cells. Verhoelst, C.H., Vandenborne, K., Severi, T., Bakker, O., Zandieh Doulabi, B., Leonard, J.L., Kühn, E.R., van der Geyten, S., Darras, V.M. Endocrinology (2002) [Pubmed]
Growth hormone acutely decreases type III iodothyronine deiodinase in chicken liver. Darras, V.M., Berghman, L.R., Vanderpooten, A., Kühn, E.R. FEBS Lett. (1992) [Pubmed]
Acute pretranslational regulation of type III iodothyronine deiodinase by growth hormone and dexamethasone in chicken embryos. Van der Geyten, S., Buys, N., Sanders, J.P., Decuypere, E., Visser, T.J., Kühn, E.R., Darras, V.M. Mol. Cell. Endocrinol. (1999) [Pubmed]

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DIO3	Bos taurus
DIO3	Canis lupus familiaris
dio3a	Danio rerio
dio3b	Danio rerio
DIO3	Homo sapiens
DIO3	Macaca mulatta
Dio3	Mus musculus
Dio3	Rattus norvegicus
dio3	Xenopus (Silurana) tropicalis

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