Disease relevance of Dio3

• Cortex type III 5-deiodinase was only increased when hyperthyroidism was induced by infusion of T3 [1].

High impact information on Dio3

• The type III iodothyronine deiodinase metabolizes the active thyroid hormones thyroxine and 3,5,3'-triiodothyronine to inactive compounds [2].
• Tilapia liver T4 ORD activity and tilapia brain and gill T3 IRD activities show very similar substrate specificities as well as similar inhibitor sensitivities as rat type II and type III iodothyronine deiodinase, respectively [3].
• A type III iodothyronine deiodinase (D-III) that inactivates thyroid hormones has been recently cloned and identified as a selenoprotein in neonatal rat skin [4].
• Epidermal growth factor and basic and acidic fibroblast growth factors produced a strong induction of 5DIII activity (25, 45-, and 50-fold, respectively) [5].
• Platelet-derived growth factor, vasopressin, and insulin-like growth factor-I induced lower 5DIII activities (3- to 6-fold) [5].

Biological context of Dio3

• The kinetics of type III iodothyronine deiodinase (5-D) in rat placenta and brain and the role of phospholipids in enzyme activity were determined [6].

Anatomical context of Dio3

• Evidence that type III iodothyronine deiodinase in rat astrocyte is a selenoprotein [4].

References