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BMP5  -  bone morphogenetic protein 5

Gallus gallus

 
 
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High impact information on BMP5

  • To test our hypothesis we implanted beads soaked in recombinant BMP5 or BMP4 into the neural tube of the chicken forebrain [1].
  • Gain-of-function experiments demonstrated that BMP5 has the same effect as other interdigital BMPs inducing apoptosis in the undifferentiated mesoderm and growth in the prechondrogenic mesenchyme [2].
  • Transcripts of Bmp5 and BMP5 protein were abundant within the cytoplasm of the fragmenting apoptotic interdigital cells in a way suggesting that delivery of BMPs into the tissue is potentiated during apoptosis [2].
  • In agreement with a possible role in the control of cell death, Bmp5 exhibited a regulated pattern of expression in the interdigital tissue [2].
  • Thereafter, BMP5 expression was restricted to the myocardium of the atrioventricular (AV) canal and outflow tract (OT) regions, where the valvuloseptal endocardial cushion tissue is induced [3].
 

Anatomical context of BMP5

 

Other interactions of BMP5

 

Analytical, diagnostic and therapeutic context of BMP5

References

  1. Ectopic bone morphogenetic proteins 5 and 4 in the chicken forebrain lead to cyclopia and holoprosencephaly. Golden, J.A., Bracilovic, A., McFadden, K.A., Beesley, J.S., Rubenstein, J.L., Grinspan, J.B. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  2. A new role for BMP5 during limb development acting through the synergic activation of Smad and MAPK pathways. Zuzarte-Luís, V., Montero, J.A., Rodriguez-León, J., Merino, R., Rodríguez-Rey, J.C., Hurlé, J.M. Dev. Biol. (2004) [Pubmed]
  3. Expression of bone morphogenetic protein-5 gene during chick heart development: possible roles in valvuloseptal endocardial cushion formation. Yamagishi, T., Nakajima, Y., Nishimatsu, S., Nohno, T., Ando, K., Nakamura, H. Anat. Rec. (2001) [Pubmed]
  4. Dynamic patterns of expression of BMP isoforms 2, 4, 5, 6, and 7 during chicken heart development. Somi, S., Buffing, A.A., Moorman, A.F., Van Den Hoff, M.J. The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology. (2004) [Pubmed]
 
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