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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

NFKBIA  -  nuclear factor of kappa light polypeptide...

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High impact information on NFKBIA

  • IkappaBalpha is a critical regulator of Rel/NF-KB-mediated gene activation [1].
  • While the repression of v-Rel was accompanied by the rapid degradation of IkappaBalpha, changes in the steady-state levels of the apoptosis inhibitors Bcl-2 and Bcl-X(L) were only observed following the onset of cell death in transformed lymphoid cells [2].
  • The ability of v-Rel to stabilize I kappa B-alpha but poorly induce Ikba mRNA expression relative to c-Rel may play a role in regulating gene expression, thereby leading to transformation [3].

References

  1. Distinct domains of IkappaBalpha regulate c-Rel in the cytoplasm and in the nucleus. Luque, I., Gélinas, C. Mol. Cell. Biol. (1998) [Pubmed]
  2. v-Rel prevents apoptosis in transformed lymphoid cells and blocks TNFalpha-induced cell death. Zong, W.X., Farrell, M., Bash, J., Gélinas, C. Oncogene (1997) [Pubmed]
  3. The relocalization of v-Rel from the nucleus to the cytoplasm coincides with induction of expression of Ikba and nfkb1 and stabilization of I kappa B-alpha. Hrdlicková, R., Nehyba, J., Roy, A., Humphries, E.H., Bose, H.R. J. Virol. (1995) [Pubmed]
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