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Gene Review

NFKBIA  -  nuclear factor of kappa light polypeptide...

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High impact information on NFKBIA

  • IkappaBalpha is a critical regulator of Rel/NF-KB-mediated gene activation [1].
  • While the repression of v-Rel was accompanied by the rapid degradation of IkappaBalpha, changes in the steady-state levels of the apoptosis inhibitors Bcl-2 and Bcl-X(L) were only observed following the onset of cell death in transformed lymphoid cells [2].
  • The ability of v-Rel to stabilize I kappa B-alpha but poorly induce Ikba mRNA expression relative to c-Rel may play a role in regulating gene expression, thereby leading to transformation [3].


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