Gene Review:
Nfkbia - nuclear factor of kappa light polypeptide...
Mus musculus
Synonyms:
AI462015, I(Kappa)B(alpha), I-kappa-B-alpha, I-kappaBalpha, IkB-alpha, ...
- IkappaBalpha deficiency results in a sustained NF-kappaB response and severe widespread dermatitis in mice. Klement, J.F., Rice, N.R., Car, B.D., Abbondanzo, S.J., Powers, G.D., Bhatt, P.H., Chen, C.H., Rosen, C.A., Stewart, C.L. Mol. Cell. Biol. (1996)
- Expression of a dominant-negative mutant inhibitor-kappaBalpha of nuclear factor-kappaB in human head and neck squamous cell carcinoma inhibits survival, proinflammatory cytokine expression, and tumor growth in vivo. Duffey, D.C., Chen, Z., Dong, G., Ondrey, F.G., Wolf, J.S., Brown, K., Siebenlist, U., Van Waes, C. Cancer Res. (1999)
- Amelioration of glucose tolerance by hepatic inhibition of nuclear factor kappaB in db/db mice. Tamura, Y., Ogihara, T., Uchida, T., Ikeda, F., Kumashiro, N., Nomiyama, T., Sato, F., Hirose, T., Tanaka, Y., Mochizuki, H., Kawamori, R., Watada, H. Diabetologia (2007)
- Neuronal activity and transcription of proinflammatory cytokines, IkappaBalpha, and iNOS in the mouse brain during acute endotoxemia and chronic infection with Trypanosoma brucei brucei. Brochu, S., Olivier, M., Rivest, S. J. Neurosci. Res. (1999)
- Evidence for a phosphorylation-independent role for Ser 32 and 36 in proteasome inhibitor-resistant (PIR) IkappaBalpha degradation in B cells. O'Connor, S., Markovina, S., Miyamoto, S. Exp. Cell Res. (2005)
- IKKbeta/NF-kappaB activation causes severe muscle wasting in mice. Cai, D., Frantz, J.D., Tawa, N.E., Melendez, P.A., Oh, B.C., Lidov, H.G., Hasselgren, P.O., Frontera, W.R., Lee, J., Glass, D.J., Shoelson, S.E. Cell (2004)
- NF-kappaB blockade and oncogenic Ras trigger invasive human epidermal neoplasia. Dajee, M., Lazarov, M., Zhang, J.Y., Cai, T., Green, C.L., Russell, A.J., Marinkovich, M.P., Tao, S., Lin, Q., Kubo, Y., Khavari, P.A. Nature (2003)
- High susceptibility to bacterial infection, but no liver dysfunction, in mice compromised for hepatocyte NF-kappaB activation. Lavon, I., Goldberg, I., Amit, S., Landsman, L., Jung, S., Tsuberi, B.Z., Barshack, I., Kopolovic, J., Galun, E., Bujard, H., Ben-Neriah, Y. Nat. Med. (2000)
- Duration of nuclear NF-kappaB action regulated by reversible acetylation. Chen Lf, n.u.l.l., Fischle, W., Verdin, E., Greene, W.C. Science (2001)
- Adenoviral gene transfer of ABIN-1 protects mice from TNF/galactosamine-induced acute liver failure and lethality. Wullaert, A., Wielockx, B., Van Huffel, S., Bogaert, V., De Geest, B., Papeleu, P., Schotte, P., El Bakkouri, K., Heyninck, K., Libert, C., Beyaert, R. Hepatology (2005)
- Curcumin suppresses the paclitaxel-induced nuclear factor-kappaB pathway in breast cancer cells and inhibits lung metastasis of human breast cancer in nude mice. Aggarwal, B.B., Shishodia, S., Takada, Y., Banerjee, S., Newman, R.A., Bueso-Ramos, C.E., Price, J.E. Clin. Cancer Res. (2005)
- The inhibitor of I kappa B alpha phosphorylation BAY 11-7082 prevents NMDA neurotoxicity in mouse hippocampal slices. Goffi, F., Boroni, F., Benarese, M., Sarnico, I., Benetti, A., Spano, P.F., Pizzi, M. Neurosci. Lett. (2005)
- Combination gene therapy for glioblastoma involving herpes simplex virus vector-mediated codelivery of mutant IkappaBalpha and HSV thymidine kinase. Moriuchi, S., Glorioso, J.C., Maruno, M., Izumoto, S., Wolfe, D., Huang, S., Cohen, J.B., Yoshimine, T. Cancer Gene Ther. (2005)
- Hepatic expression of S32A/S36A IkappaBalpha does not reduce postischemic liver injury. Okaya, T., Lentsch, A.B. J. Surg. Res. (2005)
- Suppression of TNF-alpha-induced apoptosis by NF-kappaB. Van Antwerp, D.J., Martin, S.J., Kafri, T., Green, D.R., Verma, I.M. Science (1996)
- Hepatitis C core and nonstructural 3 proteins trigger toll-like receptor 2-mediated pathways and inflammatory activation. Dolganiuc, A., Oak, S., Kodys, K., Golenbock, D.T., Finberg, R.W., Kurt-Jones, E., Szabo, G. Gastroenterology (2004)
- Recruitment of IkappaBalpha to the hes1 promoter is associated with transcriptional repression. Aguilera, C., Hoya-Arias, R., Haegeman, G., Espinosa, L., Bigas, A. Proc. Natl. Acad. Sci. U.S.A. (2004)
- NF-kappaB RelA phosphorylation regulates RelA acetylation. Chen, L.F., Williams, S.A., Mu, Y., Nakano, H., Duerr, J.M., Buckbinder, L., Greene, W.C. Mol. Cell. Biol. (2005)
- Regulation of constitutive p50/c-Rel activity via proteasome inhibitor-resistant IkappaBalpha degradation in B cells. O'Connor, S., Shumway, S.D., Amanna, I.J., Hayes, C.E., Miyamoto, S. Mol. Cell. Biol. (2004)
- Identification of a novel NF-kappaB p50-related protein in B lymphocytes. Phillips, R.J., Gustafson, S., Ghosh, S. Mol. Cell. Biol. (1996)
- Reductions in I kappa B epsilon and changes in NF-kappa B activity during B lymphocyte differentiation. Doerre, S., Mesires, K.P., Daley, K.M., McCarty, T., Knoetig, S., Corley, R.B. J. Immunol. (2005)
- Aminosalicylic acid inhibits IkappaB kinase alpha phosphorylation of IkappaBalpha in mouse intestinal epithelial cells. Yan, F., Polk, D.B. J. Biol. Chem. (1999)
- betaTrCP-mediated proteolysis of NF-kappaB1 p105 requires phosphorylation of p105 serines 927 and 932. Lang, V., Janzen, J., Fischer, G.Z., Soneji, Y., Beinke, S., Salmeron, A., Allen, H., Hay, R.T., Ben-Neriah, Y., Ley, S.C. Mol. Cell. Biol. (2003)
- IkappaB kinase-independent IkappaBalpha degradation pathway: functional NF-kappaB activity and implications for cancer therapy. Tergaonkar, V., Bottero, V., Ikawa, M., Li, Q., Verma, I.M. Mol. Cell. Biol. (2003)
- Opposing roles for NF-kappa B/Rel factors p65 and c-Rel in the modulation of neuron survival elicited by glutamate and interleukin-1beta. Pizzi, M., Goffi, F., Boroni, F., Benarese, M., Perkins, S.E., Liou, H.C., Spano, P. J. Biol. Chem. (2002)
- Involvement of reactive oxygen species in Toll-like receptor 4-dependent activation of NF-kappa B. Asehnoune, K., Strassheim, D., Mitra, S., Kim, J.Y., Abraham, E. J. Immunol. (2004)
- Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2. Deng, J., Lu, P.D., Zhang, Y., Scheuner, D., Kaufman, R.J., Sonenberg, N., Harding, H.P., Ron, D. Mol. Cell. Biol. (2004)
- Developmental and tissue-specific expression of mouse pelle-like protein kinase. Trofimova, M., Sprenkle, A.B., Green, M., Sturgill, T.W., Goebl, M.G., Harrington, M.A. J. Biol. Chem. (1996)
- Mechanisms underlying the protective potential of alpha-tocopherol (vitamin E) against haloperidol-associated neurotoxicity. Post, A., Rücker, M., Ohl, F., Uhr, M., Holsboer, F., Almeida, O.F., Michaelidis, T.M. Neuropsychopharmacology (2002)
- In vivo and in vitro sensitization of leukemic cells to adriamycin-induced apoptosis by pentoxifylline. Involvement of caspase cascades and IkappaBalpha phosphorylation. Lerma-Díaz, J.M., Hernández-Flores, G., Domínguez-Rodríguez, J.R., Ortíz-Lazareno, P.C., Gómez-Contreras, P., Cervantes-Munguía, R., Scott-Algara, D., Aguilar-Lemarroy, A., Jave-Suárez, L.F., Bravo-Cuellar, A. Immunol. Lett. (2006)
- Enhanced NF-kappaB activation and cellular function in macrophages lacking IkappaB kinase 1 (IKK1). Li, Q., Lu, Q., Bottero, V., Estepa, G., Morrison, L., Mercurio, F., Verma, I.M. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Evidence that genetic deletion of the TNF receptor p60 or p80 in macrophages modulates RANKL-induced signaling. Takada, Y., Aggarwal, B.B. Blood (2004)
- Lymphotoxin beta receptor induces sequential activation of distinct NF-kappa B factors via separate signaling pathways. Müller, J.R., Siebenlist, U. J. Biol. Chem. (2003)
- Glycogen synthase kinase 3beta functions to specify gene-specific, NF-kappaB-dependent transcription. Steinbrecher, K.A., Wilson, W., Cogswell, P.C., Baldwin, A.S. Mol. Cell. Biol. (2005)
- The IKK-2/Ikappa Balpha /NF-kappa B pathway plays a key role in the regulation of CCR3 and eotaxin-1 in fibroblasts. A critical link to dermatitis in Ikappa Balpha -deficient mice. Huber, M.A., Denk, A., Peter, R.U., Weber, L., Kraut, N., Wirth, T. J. Biol. Chem. (2002)
- Vanadate induction of NF-kappaB involves IkappaB kinase beta and SAPK/ERK kinase 1 in macrophages. Chen, F., Demers, L.M., Vallyathan, V., Ding, M., Lu, Y., Castranova, V., Shi, X. J. Biol. Chem. (1999)
- Haemorrhagic shock in mice - Intracellular signalling and immunomodulation of peritoneal macrophages' LPS response. Rani, M., Husain, B., Lendemans, S., Schade, F.U., Floh??, S. Immunobiology (2006)
- Inhibition of nuclear factor kappaB and phosphatidylinositol 3-kinase/Akt is essential for massive hepatocyte apoptosis induced by tumor necrosis factor alpha in mice. Imose, M., Nagaki, M., Naiki, T., Osawa, Y., Brenner, D.A., Asano, T., Hayashi, H., Kato, T., Moriwaki, H. Liver Int. (2003)
- Biphasic role of nuclear factor-kappa B on cell survival and COX-2 expression in SOD1 Tg astrocytes after oxygen glucose deprivation. Lee, Y.S., Song, Y.S., Giffard, R.G., Chan, P.H. J. Cereb. Blood Flow Metab. (2006)
- I kappa B overexpression in cardiomyocytes prevents NF-kappa B translocation and provides cardioprotection in trauma. Carlson, D.L., White, D.J., Maass, D.L., Nguyen, R.C., Giroir, B., Horton, J.W. Am. J. Physiol. Heart Circ. Physiol. (2003)